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NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism

NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene... Downloaded from genesdev.cshlp.org on December 3, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION flammation (Silverman and Maniatis 2001; Ghosh and NF-B mediates inhibition Karin 2002; Li and Verma 2002). There are five distinct NF-B proteins, p65/RelA, c-Rel, RelB, NF-B2/p52 and of mesenchymal cell NF-B1/p50, each containing a Rel homology domain differentiation through that mediates DNA binding and dimerization. In the ab- sence of stimuli, NF-B is sequestered predominantly in a posttranscriptional gene the cytoplasm by inhibitory IB proteins. Stimulation by silencing mechanism effectors such as TNF, interleukin-1 (IL-1), viral pro- teins, and double-stranded RNA, triggers IB phosphory- 1 1 Raquel Sitcheran, Patricia C. Cogswell, lation and degradation, NF-B nuclear translocation, and 1,2,3 transcriptional regulation of target genes (Silverman and and Albert S. Baldwin Jr. Maniatis 2001; Ghosh and Karin 2002; Li and Verma 1 2 Lineberger Comprehensive Cancer Center, Department of 2002). Generally, NF-B is described as a transcriptional Biology, University of North Carolina at Chapel Hill, activator, and there is ample data demonstrating that Chapel Hill, North Carolina 27599, USA NF-B positively regulates transcription. However, there is also some evidence that NF-B can repress transcrip- Cytokines, such as tumor necrosis factor- (TNF), po- tion. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism

Sitcheran, Raquel; Cogswell, Patricia C.; Baldwin, Albert S.
Genes & Development – Oct 1, 2003
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Publisher
Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.1114503
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Abstract

Downloaded from genesdev.cshlp.org on December 3, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION flammation (Silverman and Maniatis 2001; Ghosh and NF-B mediates inhibition Karin 2002; Li and Verma 2002). There are five distinct NF-B proteins, p65/RelA, c-Rel, RelB, NF-B2/p52 and of mesenchymal cell NF-B1/p50, each containing a Rel homology domain differentiation through that mediates DNA binding and dimerization. In the ab- sence of stimuli, NF-B is sequestered predominantly in a posttranscriptional gene the cytoplasm by inhibitory IB proteins. Stimulation by silencing mechanism effectors such as TNF, interleukin-1 (IL-1), viral pro- teins, and double-stranded RNA, triggers IB phosphory- 1 1 Raquel Sitcheran, Patricia C. Cogswell, lation and degradation, NF-B nuclear translocation, and 1,2,3 transcriptional regulation of target genes (Silverman and and Albert S. Baldwin Jr. Maniatis 2001; Ghosh and Karin 2002; Li and Verma 1 2 Lineberger Comprehensive Cancer Center, Department of 2002). Generally, NF-B is described as a transcriptional Biology, University of North Carolina at Chapel Hill, activator, and there is ample data demonstrating that Chapel Hill, North Carolina 27599, USA NF-B positively regulates transcription. However, there is also some evidence that NF-B can repress transcrip- Cytokines, such as tumor necrosis factor- (TNF), po- tion.

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Genes & Development – Unpaywall

Published: Oct 1, 2003

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