Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Both Naturally Occurring Insertions of Transposable Elements and Intermediate Frequency Polymorphisms at the achaete-scute Complex Are Associated With Variation in Bristle Number in Drosophila melanogaster

Both Naturally Occurring Insertions of Transposable Elements and Intermediate Frequency... A restriction enzyme survey of a 110-kb region including the achaete scute complex (ASC) examined 14 polymorphic molecular markers in a sample of 56 naturally occurring chromosomes. Large insertions as a class were associated with a reduction in both sternopleural and abdominal bristle number, supporting deleterious mutation-selection equilibrium models for the maintenance of quantitative genetic variation. Two polymorphic sites were independently associated with variation in bristle number measured in two genetic backgrounds as assessed by a permutation test. A 6-bp deletion near sc α is associated with sternopleural bristle number variation in both sexes and a 3.4-kb insertion between sc β and sc γ is associated with abdominal bristle number variation in females. Under an additive genetic model, the small deletion polymorphism near sc α accounts for 25% of the total X chromosome genetic variation in sternopleural bristle number, and the 3.4 kb insertion accounts for 22% of the total X chromosome variation in female abdominal bristle number. The observation of common polymorphisms associated with variation in bristle number is more parsimoniously explained by models that incorporate balancing selection or assume variants affecting bristle number are neutral, than mutation-selection equilibrium models. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genetics Oxford University Press

Both Naturally Occurring Insertions of Transposable Elements and Intermediate Frequency Polymorphisms at the achaete-scute Complex Are Associated With Variation in Bristle Number in Drosophila melanogaster

Download PDF
15 pages

 
/lp/oxford-university-press/both-naturally-occurring-insertions-of-transposable-elements-and-li9gwtk5Um

References (6)

Publisher
Oxford University Press
Copyright
© Genetics 2000
ISSN
0016-6731
eISSN
1943-2631
DOI
10.1093/genetics/154.3.1255
Publisher site
See Article on Publisher Site

Abstract

A restriction enzyme survey of a 110-kb region including the achaete scute complex (ASC) examined 14 polymorphic molecular markers in a sample of 56 naturally occurring chromosomes. Large insertions as a class were associated with a reduction in both sternopleural and abdominal bristle number, supporting deleterious mutation-selection equilibrium models for the maintenance of quantitative genetic variation. Two polymorphic sites were independently associated with variation in bristle number measured in two genetic backgrounds as assessed by a permutation test. A 6-bp deletion near sc α is associated with sternopleural bristle number variation in both sexes and a 3.4-kb insertion between sc β and sc γ is associated with abdominal bristle number variation in females. Under an additive genetic model, the small deletion polymorphism near sc α accounts for 25% of the total X chromosome genetic variation in sternopleural bristle number, and the 3.4 kb insertion accounts for 22% of the total X chromosome variation in female abdominal bristle number. The observation of common polymorphisms associated with variation in bristle number is more parsimoniously explained by models that incorporate balancing selection or assume variants affecting bristle number are neutral, than mutation-selection equilibrium models.

Journal

Genetics – Oxford University Press

Published: Mar 1, 2000

There are no references for this article.