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CELLULAR BASIS OF SKELETAL GROWTH DURING DEVELOPMENT

CELLULAR BASIS OF SKELETAL GROWTH DURING DEVELOPMENT British Medical Bulletin (1981) Vol. 37, No. 3, pp. 215-219 CELLULAR BASIS OF SKELETAL GROWTH DURING DEVELOPMENT L Wolpert division with cell density, which is reminiscent of density- dependent cell division in tissue culture (Summerbell & Wolpert, 1972). During this early phase the limb bud is flattened along its CELLULAR BASIS OF SKELETAL dorsoventral axis. On the basis of their study of the talpid mutant, in which the limb bud is much broader, Ede et al. GROWTH DURING DEVELOPMENT (1977) have suggested that the over-all form arises from the pattern of cell division and migration of the mesodermal cells. However, it is much more likely that the form of the limb is L WOLPERT PhD FRS determined by the ectodermal jacket. This has a markedly thickened region—the apical ectodermal ridge—which is most Department of Biology as Applied to Medicine developed distally and runs in an anterioposterior direction. It is The Middlesex Hospital Medical School, London not unlike the thickened edge of a hot water bottle and probably plays a similar mechanical role. Viewed in these terms, the cell 1 The vertebrate limb 2 Positional information and pattern formation proliferation of the early mesoderm expands the tissue to fill the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Medical Bulletin Oxford University Press

CELLULAR BASIS OF SKELETAL GROWTH DURING DEVELOPMENT

WOLPERT, L
British Medical Bulletin , Volume 37 (3) – Sep 1, 1981
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Publisher
Oxford University Press
Copyright
© Oxford University Press
ISSN
0007-1420
eISSN
1471-8391
DOI
10.1093/oxfordjournals.bmb.a071705
Publisher site
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Abstract

British Medical Bulletin (1981) Vol. 37, No. 3, pp. 215-219 CELLULAR BASIS OF SKELETAL GROWTH DURING DEVELOPMENT L Wolpert division with cell density, which is reminiscent of density- dependent cell division in tissue culture (Summerbell & Wolpert, 1972). During this early phase the limb bud is flattened along its CELLULAR BASIS OF SKELETAL dorsoventral axis. On the basis of their study of the talpid mutant, in which the limb bud is much broader, Ede et al. GROWTH DURING DEVELOPMENT (1977) have suggested that the over-all form arises from the pattern of cell division and migration of the mesodermal cells. However, it is much more likely that the form of the limb is L WOLPERT PhD FRS determined by the ectodermal jacket. This has a markedly thickened region—the apical ectodermal ridge—which is most Department of Biology as Applied to Medicine developed distally and runs in an anterioposterior direction. It is The Middlesex Hospital Medical School, London not unlike the thickened edge of a hot water bottle and probably plays a similar mechanical role. Viewed in these terms, the cell 1 The vertebrate limb 2 Positional information and pattern formation proliferation of the early mesoderm expands the tissue to fill the

Journal

British Medical Bulletin – Oxford University Press

Published: Sep 1, 1981

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