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Role of Myofibroblasts at the Invasion Front

Role of Myofibroblasts at the Invasion Front Abstract Tumor progression occurs within a microecosystem, where cancer cells and myofibroblasts exchange proteinases and cytokines that promote growth directly through stimulation of proliferation and survival, as well as invasion through local proteolysis of the extracellular matrix and stimulation of motility. Myofibroblasts maintain the capacity of fibroblasts to induce differentiation. Fibroblasts are the main source of tumorassociated myofibroblasts. The transition to myofibroblasts also occurs in noncancerous situations. This transition is modulated by mechanical stress and cytokines, amongst which transforming growth factorβ. The crosstalk between cancer cells and myofibroblasts illustrates the microecosystem of tumor invasion. In order to consider myofibroblasts as a possibly new target for cancer therapy, further characterization of the molecular crosstalk between myofibroblasts and cancer cells is required. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biological Chemistry de Gruyter

Role of Myofibroblasts at the Invasion Front

Wever, Olivier De; Mareel, Marc
Biological Chemistry , Volume 383 (1) – Jan 23, 2002
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References (163)

Publisher
de Gruyter
Copyright
Copyright © 2002 by the
ISSN
1431-6730
DOI
10.1515/BC.2002.006
pmid
11928823
Publisher site
See Article on Publisher Site

Abstract

Abstract Tumor progression occurs within a microecosystem, where cancer cells and myofibroblasts exchange proteinases and cytokines that promote growth directly through stimulation of proliferation and survival, as well as invasion through local proteolysis of the extracellular matrix and stimulation of motility. Myofibroblasts maintain the capacity of fibroblasts to induce differentiation. Fibroblasts are the main source of tumorassociated myofibroblasts. The transition to myofibroblasts also occurs in noncancerous situations. This transition is modulated by mechanical stress and cytokines, amongst which transforming growth factorβ. The crosstalk between cancer cells and myofibroblasts illustrates the microecosystem of tumor invasion. In order to consider myofibroblasts as a possibly new target for cancer therapy, further characterization of the molecular crosstalk between myofibroblasts and cancer cells is required.

Journal

Biological Chemistry – de Gruyter

Published: Jan 23, 2002

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