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/lp/karger/changes-in-gastric-mucosal-morphology-capillary-permeability-and-blood-m5Pv0wFq6y
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- Publisher
- Karger
- Copyright
- © 1980 S. Karger AG, Basel
- ISSN
- 0014-312X
- eISSN
- 1421-9921
- DOI
- 10.1159/000128116
- Publisher site
- See Article on Publisher Site
Abstract
In the present investigation gastric morphology, blood flow, vascular permeability and water content were studied in cat stomachs with acetic acid-induced gastritis at different time intervals up to 3 days after induction of gastritis. The morphological changes including mucosal erosions, edema and hemorrhage showed normalization within 3 days. The mucosa and muscularis blood flow remained essentially unchanged compared with pre-gastritis values and with the control group. Gastritis was associated with leakage of circulating albumin into the stomach wall most pronounced 4 h after the induction of gastritis. The water content was high at 4 and 24 h after induction of gastritis with almost normalization at 3 days. The morphological characteristics of our model are very similar to those observed in man. Leakage of circulating albumin into the gastric wall seems to be the best parameter for quantification of the inflammatory changes found in acute gastritis, while blood flow seems to be a less important parameter.
Journal
European Surgical Research – Karger
Published: Jan 1, 1980
Keywords: Gastritis; Gastric mucosa; Gastric mucosa blood supply; Gastritis pathology; Capillary permeability; Microspheres