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Developmental modulation of an identified electrical synapse: functional uncoupling

Developmental modulation of an identified electrical synapse: functional uncoupling ERIC R. KEL Division of Neurobiology Behavior, Departments of Physiology College of Physicians Surgeons of Columbia University, New York State Psychiatric Institute, New York City 10032 Psychiatry, SUMMARY CONCLUSIONS I. The identifiability of the giant cholinergic neurons R2 LPI, ofAplysia calzfornica throughout the postmetamorphic stages in the animal’s life makes them uniquely suited for al studies. 2. We have looked at late stages in the differentiation of the identified that connects the two cells found that the undergoes a profound paradoxical change in effectiveness during the final stages of . In juvenile animals, the tends to be highly effective with the result that Rz LPI, often fire in synchrony, whereas in the adult the cells are functionally uncoupled are activated independently. 3. The functional uncoupling of the cells is due to growth of the axons that the connects, leading to shunting of synaptic current; the shunting overrides a concurrent increase in synaptic conductance. 4. The fact that steps in the final differentiation of this occur at the end of the juvenile period suggests that of s resembles that of chemical ones in involving a number of al steps taking place over a considerable period of time, in this http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

Developmental modulation of an identified electrical synapse: functional uncoupling

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Publisher
The American Physiological Society
Copyright
Copyright © 1980 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
Publisher site
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Abstract

ERIC R. KEL Division of Neurobiology Behavior, Departments of Physiology College of Physicians Surgeons of Columbia University, New York State Psychiatric Institute, New York City 10032 Psychiatry, SUMMARY CONCLUSIONS I. The identifiability of the giant cholinergic neurons R2 LPI, ofAplysia calzfornica throughout the postmetamorphic stages in the animal’s life makes them uniquely suited for al studies. 2. We have looked at late stages in the differentiation of the identified that connects the two cells found that the undergoes a profound paradoxical change in effectiveness during the final stages of . In juvenile animals, the tends to be highly effective with the result that Rz LPI, often fire in synchrony, whereas in the adult the cells are functionally uncoupled are activated independently. 3. The functional uncoupling of the cells is due to growth of the axons that the connects, leading to shunting of synaptic current; the shunting overrides a concurrent increase in synaptic conductance. 4. The fact that steps in the final differentiation of this occur at the end of the juvenile period suggests that of s resembles that of chemical ones in involving a number of al steps taking place over a considerable period of time, in this

Journal

Journal of Neurophysiology – The American Physiological Society

Published: Sep 1, 1980

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