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References 8 and 9 reveal the three-dimensional structure of IL-33 and the molecular mechanisms of high-affinity binding to ST2 -
H. Morita, K. Arae, H. Unno, Kousuke Miyauchi, S. Toyama, Aya Nambu, K. Oboki, T. Ohno, K. Motomura, A. Matsuda, Sachiko Yamaguchi, S. Narushima, Naoki Kajiwara, M. Iikura, H. Suto, A. McKenzie, Takao Takahashi, H. Karasuyama, K. Okumura, M. Azuma, K. Moro, C. Akdis, S. Galli, S. Koyasu, M. Kubo, K. Sudo, H. Saito, Kenji Matsumoto, S. Nakae (2015)
An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers.Immunity, 43 1
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A. Buck, G. Coakley, F. Simbari, H. McSorley, Juan Quintana, T. Bihan, Sujai Kumar, C. Abreu-Goodger, M. Lear, Y. Harcus, A. Ceroni, S. Babayan, M. Blaxter, A. Ivens, R. Maizels (2014)
Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunityNature Communications, 5
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IL-1β-Driven ST2L Expression Promotes Maturation Resistance in Rapamycin-Conditioned Dendritic Cells1The Journal of Immunology, 181
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Benjamin Matta, D. Reichenbach, Xiaoli Zhang, L. Mathews, Brent Koehn, Gaelen Dwyer, Jeremy Lott, F. Uhl, D. Pfeifer, Colby Feser, Michelle Smith, Quan Liu, R. Zeiser, B. Blazar, H. Turnquist (2016)
Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD.Blood, 128 3
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A Novel Therapy of Murine Collagen-Induced Arthritis with Soluble T1/ST21The Journal of Immunology, 173
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(2014)
This study shows that genetic deletion of the N-terminal chromatin-binding nuclear domain of IL-33 results in multi-organ inflammation and ST2-dependent lethality -
J. Chapuis, D. Hot, F. Hansmannel, O. Kerdraon, S. Ferreira, C. Hubans, C. Maurage, L. Huot, F. Bensemain, G. Laumet, A. Ayral, N. Fievet, J. Hauw, S. DeKosky, Y. Lemoine, T. Iwatsubo, F. Wavrant-DeVrièze, J. Dartigues, C. Tzourio, L. Buée, F. Pasquier, C. Berr, D. Mann, C. Lendon, A. Alpérovitch, M. Kamboh, P. Amouyel, J. Lambert (2009)
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's diseaseMolecular Psychiatry, 14
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C. Baumann, Weldy Bonilla, A. Fröhlich, C. Helmstetter, M. Peine, A. Hegazy, D. Pinschewer, M. Löhning (2015)
T-bet– and STAT4–dependent IL-33 receptor expression directly promotes antiviral Th1 cell responsesProceedings of the National Academy of Sciences, 112
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T. Savinko, S. Matikainen, U. Saarialho‐kere, M. Lehto, Guoying Wang, S. Lehtimäki, Piia Karisola, T. Reunala, H. Wolff, A. Lauerma, H. Alenius (2012)
IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors.The Journal of investigative dermatology, 132 5
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ES Cohen (2015)
Oxidation of the alarmin IL-33 regulates ST2-dependent inflammationNat. Commun., 6
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This study shows that IL-33 is important in protecting the host against infections -
D. Zaiss, W. Gause, L. Osborne, D. Artis (2015)
Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair.Immunity, 42 2
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This study reveals a T reg cell-supportive role for endogenous IL-33 and provides molecular evidence that IL-23 can inhibit IL-33-mediated signalling in T reg cells -
A. Flaczyk, C. Duerr, Mitra Shourian, Erin Lafferty, Jörg Fritz, S. Qureshi (2013)
IL-33 Signaling Regulates Innate and Adaptive Immunity to Cryptococcus neoformansThe Journal of Immunology, 191
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IL-33 reduces the development of atherosclerosisThe Journal of Experimental Medicine, 205
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Ari Molofsky, A. Savage, R. Locksley (2015)
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Emma Lefrançais, S. Roga, Violette Gautier, Anne Gonzalez-de-Peredo, B. Monsarrat, J. Girard, C. Cayrol (2012)
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Qianting Yang, Gang Li, Yi-bei Zhu, Lin Liu, Elizabeth Chen, H. Turnquist, Xueguang Zhang, O. Finn, Xinchun Chen, B. Lu (2011)
IL‐33 synergizes with TCR and IL‐12 signaling to promote the effector function of CD8+ T cellsEuropean Journal of Immunology, 41
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(2015)
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Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritisProceedings of the National Academy of Sciences, 107
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H. Turnquist, Zhen-Min Zhao, B. Rosborough, Quan Liu, A. Castellaneta, K. Isse, Zhiliang Wang, Megan Lang, D. Stolz, X. Zheng, A. Demetris, Fooyew Liew, Kathryn Wood, Angus Thomson (2011)
IL-33 Expands Suppressive CD11b+ Gr-1int and Regulatory T Cells, including ST2L+ Foxp3+ Cells, and Mediates Regulatory T Cell-Dependent Promotion of Cardiac Allograft SurvivalThe Journal of Immunology, 187
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M. Mildner, A. Storka, M. Lichtenauer, V. Mlitz, M. Ghannadan, K. Hoetzenecker, S. Nickl, B. Dome, E. Tschachler, H. Ankersmit (2010)
Primary sources and immunological prerequisites for sST2 secretion in humans.Cardiovascular research, 87 4
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RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency HematopoiesisCell, 157
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IL‐33 attenuates EAE by suppressing IL‐17 and IFN‐γ production and inducing alternatively activated macrophagesEuropean Journal of Immunology, 42
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Yasutomo Imai, K. Yasuda, Y. Sakaguchi, T. Haneda, H. Mizutani, T. Yoshimoto, K. Nakanishi, K. Yamanishi (2013)
Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in miceProceedings of the National Academy of Sciences, 110
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L. Monticelli, Gregory Sonnenberg, Michael Abt, T. Alenghat, Carly Ziegler, Travis Doering, Jill Angelosanto, B. Laidlaw, Cliff Yang, Taheri Sathaliyawala, Masaru Kubota, D. Turner, J. Diamond, A. Goldrath, D. Farber, R. Collman, E. Wherry, D. Artis (2011)
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virusNature Immunology, 12
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D. Reichenbach, V. Schwarze, Benjamin Matta, V. Tkachev, Elisabeth Lieberknecht, Quan Liu, Brent Koehn, D. Pfeifer, P. Taylor, G. Prinz, H. Dierbach, N. Stickel, Yvonne Beck, M. Warncke, T. Junt, A. Schmitt-Graeff, S. Nakae, M. Follo, T. Wertheimer, Lukas Schwab, J. Devlin, Simon Watkins, J. Duyster, J. Ferrara, H. Turnquist, R. Zeiser, B. Blazar (2015)
The IL-33/ST2 axis augments effector T-cell responses during acute GVHD.Blood, 125 20
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N. Millar, D. Gilchrist, M. Akbar, J. Reilly, S. Kerr, A. Campbell, G. Murrell, F. Liew, M. Kurowska-Stolarska, I. McInnes (2015)
MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon diseaseNature Communications, 6
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S. Kamijo, H. Takeda, T. Tokura, Mayu Suzuki, K. Inui, M. Hara, H. Matsuda, A. Matsuda, K. Oboki, T. Ohno, H. Saito, S. Nakae, K. Sudo, H. Suto, S. Ichikawa, H. Ogawa, K. Okumura, T. Takai (2013)
IL-33–Mediated Innate Response and Adaptive Immune Cells Contribute to Maximum Responses of Protease Allergen–Induced Allergic Airway InflammationThe Journal of Immunology, 190
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M. Rank, Takao Kobayashi, H. Kozaki, K. Bartemes, D. Squillace, H. Kita (2009)
IL-33-activated dendritic cells induce an atypical TH2-type response.The Journal of allergy and clinical immunology, 123 5
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Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33–LacZ Gene Trap Reporter StrainThe Journal of Immunology, 188
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Unique Temporal and Spatial Expression Patterns of IL-33 in Ovaries during Ovulation and Estrous Cycle Are Associated with Ovarian Tissue HomeostasisThe Journal of Immunology, 193
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Vascular Biology , Atherosclerosis and Endothelium Biology Nuclear Interleukin-33 Is Generally Expressed in Resting Endothelium but Rapidly Lost upon Angiogenic or Proinflammatory Activation -
Clare Hardman, V. Panova, A. McKenzie (2012)
IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammationEuropean Journal of Immunology, 43
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S. Villalta, Wendy Rosenthal, L. Martinez, A. Kaur, T. Sparwasser, J. Tidball, M. Margeta, M. Spencer, J. Bluestone (2014)
Regulatory T cells suppress muscle inflammation and injury in muscular dystrophyScience Translational Medicine, 6
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Emma Lefrançais, A. Duval, Emilie Mirey, S. Roga, E. Espinosa, C. Cayrol, J. Girard (2014)
Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cellsProceedings of the National Academy of Sciences, 111
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Mark Lugt, T. Braun, S. Hanash, J. Ritz, V. Ho, J. Antin, Qing Zhang, Chee‐Hong Wong, Hong Wang, Alice Chin, A. Gomez, Andrew Harris, J. Levine, S. Choi, D. Couriel, P. Reddy, J. Ferrara, S. Paczesny (2013)
ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death.The New England journal of medicine, 369 6
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(1998)
This work shows that ST2 is selectively and stably expressed by T H 2 cells and mediates T H 2 cell functions -
Damo Xu, W. Chan, B. Leung, F. Huang, R. Wheeler, D. Piedrafita, J. Robinson, F. Liew (1998)
Selective Expression of a Stable Cell Surface Molecule on Type 2 but Not Type 1 Helper T CellsThe Journal of Experimental Medicine, 187
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T. Hoyler, Christoph Klose, A. Souabni, Adriana Turqueti‐Neves, D. Pfeifer, E. Rawlins, D. Voehringer, M. Busslinger, A. Diefenbach (2012)
The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells.Immunity, 37 4
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H. Turnquist, Jon Cardinal, C. Macedo, B. Rosborough, T. Sumpter, D. Geller, D. Metes, A. Thomson (2010)
mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS.Blood, 115 23
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Jin-Tai Yu, Jing-hui Song, Nai-dong Wang, Zhong-Chen Wu, Qun Zhang, N. Zhang, Wei Zhang, S. Xuan, L. Tan (2012)
Implication of IL-33 gene polymorphism in Chinese patients with Alzheimer's diseaseNeurobiology of Aging, 33
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Guo-wei Han, Liuyuan Zeng, Chun-xiang Liang, B. Cheng, Bing-Sheng Yu, Hao-miao Li, F. Zeng, Shao-yu Liu (2011)
Serum levels of IL-33 is increased in patients with ankylosing spondylitisClinical Rheumatology, 30
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K. Oboki, T. Ohno, Naoki Kajiwara, K. Arae, H. Morita, Akina Ishii, Aya Nambu, T. Abe, H. Kiyonari, Kenji Matsumoto, K. Sudo, K. Okumura, H. Saito, S. Nakae (2010)
IL-33 is a crucial amplifier of innate rather than acquired immunityProceedings of the National Academy of Sciences, 107
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B. Stolarski, M. Kurowska-Stolarska, P. Kewin, Damo Xu, F. Liew (2010)
IL-33 Exacerbates Eosinophil-Mediated Airway InflammationThe Journal of Immunology, 185
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B. Received, H. Zimmerman, E. Fletcher, A. Wiener (1963)
TransplantationPostgraduate Medical Journal, 39
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Xin Gao, Xue-Feng Wang, Qianting Yang, Xin Zhao, W. Wen, Gang Li, Junfeng Lu, Wenxin Qin, Y. Qi, F. Xie, Jingting Jiang, Changping Wu, Xueguang Zhang, Xinchun Chen, H. Turnquist, Yi-bei Zhu, B. Lu (2015)
Tumoral Expression of IL-33 Inhibits Tumor Growth and Modifies the Tumor Microenvironment through CD8+ T and NK CellsThe Journal of Immunology, 194
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Chun Li, R. Mu, Jianping Guo, Xinyu Wu, X. Tu, Xu Liu, F. Hu, Shiwei Guo, Jia-xin Zhu, Huji Xu, Zhanguo Li (2014)
Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritisArthritis Research & Therapy, 16
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L. Hazlett, S. Mcclellan, R. Barrett, Xi Huang, Yunfan Zhang, Minhao Wu, N. Rooijen, E. Szliter (2010)
IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis.Investigative ophthalmology & visual science, 51 3
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H. Xi, K. Katschke, Yun Li, Tom Truong, Wyne Lee, L. Diehl, Linda Rangell, Jianhua Tao, Rommel Arceo, J. Eastham‐Anderson, J. Hackney, A. Iglesias, J. Cote-Sierra, J. Elstrott, R. Weimer, M. Campagne (2016)
IL-33 amplifies an innate immune response in the degenerating retinaThe Journal of Experimental Medicine, 213
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Shafaqat Ali, A. Mohs, Meike Thomas, J. Klare, R. Ross, M. Schmitz, Michael Martin (2011)
The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF-κB To Dampen NF-κB–Stimulated Gene TranscriptionThe Journal of Immunology, 187
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Anaïs Levescot, S. Flamant, S. Basbous, F. Jacomet, O. Féraud, Elvire Bourgeois, M. Bonnet, C. Giraud, L. Roy, A. Barra, J. Chomel, A. Turhan, F. Guilhot, J. Girard, J. Gombert, A. Herbelin (2014)
BCR-ABL-induced deregulation of the IL-33/ST2 pathway in CD34+ progenitors from chronic myeloid leukemia patients.Cancer research, 74 10
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E. Brint, Damo Xu, Haiying Liu, A. Dunne, A. McKenzie, L. O’Neill, F. Liew (2004)
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin toleranceNature Immunology, 5
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Janine Coombes, Christopher Hunter (2015)
Immunity to Toxoplasma gondii – into the 21st centuryParasite Immunology, 37
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S. Gadani, J. Walsh, I. Smirnov, Jingjing Zheng, J. Kipnis (2015)
The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS InjuryNeuron, 85
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J. Bessa, C. Meyer, Maria Mudry, Sonja Schlicht, S. Smith, A. Iglesias, J. Cote-Sierra (2014)
Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation.Journal of autoimmunity, 55
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D. Talabot‐Ayer, C. Lamacchia, C. Gabay, G. Palmer (2009)
Interleukin-33 Is Biologically Active Independently of Caspase-1 Cleavage*The Journal of Biological Chemistry, 284
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K. Oshikawa, K. Yanagisawa, Shinobu Tominaga, Yukihiko Sugiyama (2002)
Expression and function of the ST2 gene in a murine model of allergic airway inflammationClinical & Experimental Allergy, 32
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J. Hoogerwerf, M. Tanck, M. Zoelen, X. Wittebole, P. Laterre, T. Poll (2010)
Soluble ST2 plasma concentrations predict mortality in severe sepsisIntensive Care Medicine, 36
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A. Besnard, R. Guabiraba, W. Niedbala, J. Palomo, F. Reverchon, Tovah Shaw, K. Couper, B. Ryffel, F. Liew (2015)
IL-33-Mediated Protection against Experimental Cerebral Malaria Is Linked to Induction of Type 2 Innate Lymphoid Cells, M2 Macrophages and Regulatory T CellsPLoS Pathogens, 11
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G. Walzl, S. Matthews, S. Kendall, J. Gutiérrez-Ramos, A. Coyle, P. Openshaw, T. Hussell (2001)
Inhibition of T1/St2 during Respiratory Syncytial Virus Infection Prevents T Helper Cell Type 2 (Th2)- but Not Th1-Driven ImmunopathologyThe Journal of Experimental Medicine, 193
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T. Miyagaki, M. Sugaya, H. Yokobayashi, Toyoaki Kato, H. Ohmatsu, H. Fujita, H. Saeki, Y. Kikuchi, T. Tamaki, S. Sato (2011)
High levels of soluble ST2 and low levels of IL-33 in sera of patients with HIV infection.The Journal of investigative dermatology, 131 3
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Xi Liu, M. Hammel, Yanfeng He, J. Tainer, U. Jeng, Linqi Zhang, Shuying Wang, Xinquan Wang (2013)
Structural insights into the interaction of IL-33 with its receptorsProceedings of the National Academy of Sciences, 110
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XuD HumphreysNE (2008)
IL-33, a potent inducer of adaptive immunity to intestinal nematodes.Journal of Immunology
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A. Masamune, Takashi Watanabe, K. Kikuta, K. Satoh, A. Kanno, T. Shimosegawa (2010)
Nuclear expression of interleukin-33 in pancreatic stellate cells.American journal of physiology. Gastrointestinal and liver physiology, 299 4
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D. Préfontaine, S. Lajoie-Kadoch, S. Foley, Séverine Audusseau, R. Olivenstein, A. Halayko, C. Lemière, James Martin, Q. Hamid (2009)
Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells1The Journal of Immunology, 183
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Suyoung Bae, Taebong Kang, Jaewoo Hong, Siyoung Lee, Jida Choi, H. Jhun, Areum Kwak, Kwangwon Hong, Eunsom Kim, Seunghyun Jo, Soohyun Kim (2012)
Contradictory Functions (Activation/Termination) of Neutrophil Proteinase 3 Enzyme (PR3) in Interleukin-33 Biological Activity*The Journal of Biological Chemistry, 287
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AM Kuchler (2008)
Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activationAm. J. Pathol., 173
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A. Miller, D. Asquith, A. Hueber, L. Anderson, W. Holmes, A. Mckenzie, Damo Xu, N. Sattar, I. McInnes, F. Liew (2010)
Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in MiceCirculation Research, 107
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H. Yin, Xiangyong Li, Shilian Hu, Tao Liu, B. Yuan, Qian Ni, Fang Lan, Xiaochun Luo, H. Gu, F. Zheng (2013)
IL-33 promotes Staphylococcus aureus-infected wound healing in mice.International immunopharmacology, 17 2
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P. Kropf, Q. Bickle, S. Herath, R. Klemenz, I. Müller (2002)
Organ‐specific distribution of CD4+ T1/ST2+ Th2 cells in Leishmania major infectionEuropean Journal of Immunology, 32
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R. Gazzinelli, M. Wysocka, S. Hayashi, E. Denkers, S. Hieny, P. Caspar, G. Trinchieri, A. Sher (1994)
Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.Journal of immunology, 153 6
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R. Aoki, T. Kawamura, F. Goshima, Y. Ogawa, S. Nakae, A. Nakao, K. Moriishi, Y. Nishiyama, S. Shimada (2013)
Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production.The Journal of investigative dermatology, 133 9
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Michael Nelson, Benjamin Christmann, Jessica Werner, Allison Metz, J. Trevor, C. Lowell, C. Steele (2011)
IL-33 and M2a Alveolar Macrophages Promote Lung Defense against the Atypical Fungal Pathogen Pneumocystis murinaThe Journal of Immunology, 186
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M. Hepworth, M. Maurer, S. Hartmann (2012)
Regulation of type 2 immunity to helminths by mast cellsGut Microbes, 3
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Amal Hasan, F. Al-Ghimlas, Samia Warsame, Asma Al-Hubail, R. Ahmad, A. Bennakhi, M. Al-Arouj, K. Behbehani, M. Dehbi, S. Dermime (2014)
IL-33 is negatively associated with the BMI and confers a protective lipid/metabolic profile in non-diabetic but not diabetic subjectsBMC Immunology, 15
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K. Bartemes, K. Iijima, Takao Kobayashi, G. Kephart, A. McKenzie, H. Kita (2012)
IL-33–Responsive Lineage−CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the LungsThe Journal of Immunology, 188
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M. Löhning, A. Stroehmann, A. Coyle, J. Grogan, S. Lin, J. Gutiérrez-Ramos, D. Levinson, Andreas Radbruch, T. Kamradt (1998)
T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function.Proceedings of the National Academy of Sciences of the United States of America, 95 12
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Min-Woo Lee, J. Odegaard, Lata Mukundan, Yifu Qiu, Ari Molofsky, J. Nussbaum, K. Yun, R. Locksley, A. Chawla (2015)
Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat BiogenesisCell, 160
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G. Eberl, J. Santo, É. Vivier (2014)
The brave new world of innate lymphoid cellsNature Immunology, 16
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James Lee, E. Seppanen, J. Patel, M. Rodero, K. Khosrotehrani (2016)
ST2 receptor invalidation maintains wound inflammation, delays healing and increases fibrosisExperimental Dermatology, 25
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(2009)
References 16 and 20 show that full length IL-33 is biologically active and functions as an alarmin, is released after cellular necrosis -
This study and reference 15 use IL-33-and ST2-deficient mice to demonstrate the role of IL-33 in type 1 immune responses during viral infections -
Pierrick Marvie, M. Lisbonne, A. L'helgoualc'h, M. Rauch, B. Turlin, L. Preisser, Katia Bourd-Boittin, N. Théret, H. Gascan, C. Piquet-Pellorce, M. Samson (2009)
Interleukin-33 overexpression is associated with liver fibrosis in mice and humansJournal of Cellular and Molecular Medicine, 14
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L. Monticelli, L. Osborne, M. Noti, Sara Tran, D. Zaiss, D. Artis (2015)
IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactionsProceedings of the National Academy of Sciences, 112
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L. Duan, Jie Chen, Hongwei Zhang, H. Yang, P. Zhu, Ali Xiong, Quansong Xia, F. Zheng, Z. Tan, F. Gong, M. Fang (2012)
Interleukin-33 Ameliorates Experimental Colitis through Promoting Th2/Foxp3+ Regulatory T-Cell Responses in MiceMolecular Medicine, 18
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M. Moffatt, I. Gut, F. Demenais, D. Strachan, E. Bouzigon, S. Heath, E. Mutius, M. Farrall, M. Lathrop, W. Cookson (2010)
A large-scale, consortium-based genomewide association study of asthma.The New England journal of medicine, 363 13
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Chad Hudson, G. Christophi, Ross Gruber, Joel Wilmore, D. Lawrence, P. Massa (2008)
Induction of IL‐33 expression and activity in central nervous system gliaJournal of Leukocyte Biology, 84
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M. Komai‐Koma, D. Gilchrist, A. McKenzie, C. Goodyear, Damo Xu, F. Liew (2011)
IL-33 Activates B1 Cells and Exacerbates Contact SensitivityThe Journal of Immunology, 186
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(2012)
This study and reference 49 show that inflammatory proteases process full length IL-33 into shorter forms that have greatly increased biological activity -
G. Otto, M. Sossdorf, R. Claus, J. Rödel, K. Menge, K. Reinhart, M. Bauer, N. Riedemann (2011)
The late phase of sepsis is characterized by an increased microbiological burden and death rateCritical Care, 15
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Dalia Burzyn, Wilson Kuswanto, D. Kolodin, J. Shadrach, M. Cerletti, Y. Jang, Esen Sefik, T. Tan, A. Wagers, C. Benoist, D. Mathis (2013)
A Special Population of Regulatory T Cells Potentiates Muscle RepairCell, 155
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Jing Zhao, Jianxin Wei, R. Mialki, Daniel Mallampalli, Bill Chen, T. Coon, C. Zou, R. Mallampalli, Yutong Zhao (2012)
F-box protein FBXL19–mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammationNature Immunology, 13
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R. Sesti-Costa, G. Silva, J. Proença-Módena, D. Carlos, M. Silva, J. Alves-Filho, E. Arruda, F. Liew, J. Silva (2013)
The IL-33/ST2 Pathway Controls Coxsackievirus B5–Induced Experimental PancreatitisThe Journal of Immunology, 191
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Weldy Bonilla, A. Fröhlich, K. Senn, S. Kallert, Marylise Fernandez, Susan Johnson, M. Kreutzfeldt, A. Hegazy, Christina Schrick, P. Fallon, R. Klemenz, S. Nakae, H. Adler, D. Merkler, M. Löhning, D. Pinschewer (2012)
The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell ResponsesScience, 335
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H. Kayamuro, Y. Yoshioka, Y. Abe, S. Arita, K. Katayama, T. Nomura, T. Yoshikawa, Ritsuko Kubota-Koketsu, K. Ikuta, S. Okamoto, Y. Mori, J. Kunisawa, H. Kiyono, N. Itoh, K. Nagano, H. Kamada, Y. Tsutsumi, S. Tsunoda (2010)
Interleukin-1 Family Cytokines as Mucosal Vaccine Adjuvants for Induction of Protective Immunity against Influenza VirusJournal of Virology, 84
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Jonathan Brestoff, Brian Kim, S. Saenz, Rachel Stine, L. Monticelli, Gregory Sonnenberg, J. Thome, D. Farber, K. Lutfy, P. Seale, D. Artis (2014)
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesityNature, 519
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Dong Li, R. Guabiraba, A. Besnard, M. Komai‐Koma, M. Jabir, Li Zhang, G. Graham, M. Kurowska-Stolarska, F. Liew, C. McSharry, Damo Xu (2014)
IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in miceThe Journal of Allergy and Clinical Immunology, 134
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D. Neill, S. Wong, A. Bellosi, R. Flynn, M. Daly, Theresa Langford, C. Bucks, C. Kane, P. Fallon, R. Pannell, H. Jolin, A. McKenzie (2010)
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunityNature, 464
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G. Palmer, D. Talabot‐Ayer, C. Lamacchia, D. Toy, C. Seemayer, S. Viatte, A. Finckh, Dirk Smith, C. Gabay (2009)
Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis.Arthritis and rheumatism, 60 3
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Daniel Piehler, Andreas Grahnert, Maria Eschke, T. Richter, Gabriele Köhler, Werner Stenzel, G. Alber (2012)
T1/ST2 promotes T helper 2 cell activation and polyfunctionality in bronchopulmonary mycosisMucosal Immunology, 6
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Chris Schiering, T. Krausgruber, Agnieszka Chomka, A. Fröhlich, Krista Adelmann, E. Wohlfert, J. Pott, T. Griseri, J. Bollrath, A. Hegazy, O. Harrison, B. Owens, M. Löhning, Y. Belkaid, P. Fallon, F. Powrie (2014)
The Alarmin IL-33 Promotes Regulatory T Cell Function in the IntestineNature, 513
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Damo Xu, Hui-Rong Jiang, P. Kewin, Yubin Li, R. Mu, A. Fraser, N. Pitman, M. Kurowska-Stolarska, A. Mckenzie, I. McInnes, F. Liew (2008)
IL-33 exacerbates antigen-induced arthritis by activating mast cellsProceedings of the National Academy of Sciences, 105
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J. Turner, P. Morrison, C. Wilhelm, M. Wilson, H. Ahlfors, J. Renauld, U. Panzer, H. Helmby, B. Stockinger (2013)
IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammationThe Journal of Experimental Medicine, 210
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Hongnga Le, Vuvi Tran, Wonyoung Kim, Juyang Kim, H. Cho, B. Kwon (2012)
IL-33 Priming Regulates Multiple Steps of the Neutrophil-Mediated Anti-Candida albicans Response by Modulating TLR and Dectin-1 SignalsThe Journal of Immunology, 189
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Jilu Zhang, A. Ramadan, B. Griesenauer, Wei Li, M. Turner, Chen Liu, R. Kapur, H. Hanenberg, B. Blazar, I. Tawara, S. Paczesny (2015)
ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host diseaseScience Translational Medicine, 7
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(2015)
This work established that T cell receptorindependent, IL-33-driven upregulation of AREG supports lung epithelial integrity during viral infections -
L. Kim, R. Morita, Yasushi Kobayashi, S. Eisenbarth, C. Lee, J. Elias, E. Eynon, R. Flavell (2015)
AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mitesProceedings of the National Academy of Sciences, 112
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(2011)
An IL‐9 fate reporter demonstrates the induction of an innate IL‐9 response in lung inflammation -
T. Mosmann, R. Coffman (1989)
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.Annual review of immunology, 7
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Jon Sponheim, J. Pollheimer, Trine Olsen, J. Balogh, C. Hammarström, T. Loos, M. Kasprzycka, D. Sørensen, H. Nilsen, Axel Küchler, M. Vatn, G. Haraldsen (2010)
Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts.The American journal of pathology, 177 6
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Yuefeng Huang, W. Paul (2015)
Inflammatory group 2 innate lymphoid cells.International immunology, 28 1
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M. Kurowska-Stolarska, B. Stolarski, P. Kewin, G. Murphy, C. Corrigan, S. Ying, N. Pitman, A. Mirchandani, Batika Rana, N. Rooijen, M. Shepherd, C. McSharry, I. McInnes, Damo Xu, F. Liew (2009)
IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation1The Journal of Immunology, 183
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C. Cayrol, J. Girard (2014)
IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy.Current opinion in immunology, 31
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T. Halim, Ramona Krauss, A. Sun, F. Takei (2012)
Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation.Immunity, 36 3
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Benjamin Matta, Jeremy Lott, L. Mathews, Quan Liu, B. Rosborough, B. Blazar, H. Turnquist (2014)
IL-33 Is an Unconventional Alarmin That Stimulates IL-2 Secretion by Dendritic Cells To Selectively Expand IL-33R/ST2+ Regulatory T CellsThe Journal of Immunology, 193
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C. Cayrol, J. Girard (2009)
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1Proceedings of the National Academy of Sciences, 106
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Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1FEBS Letters, 318
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Alternative promoter usage of the Fos‐responsive gene Fit‐1 generates mRNA isoforms coding for either secreted or membrane‐bound proteins related to the IL‐1 receptor.The EMBO Journal, 13
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Aniuska Becerra, Rajas Warke, N. Bosch, A. Rothman, I. Bosch (2008)
Elevated levels of soluble ST2 protein in dengue virus infected patients.Cytokine, 41 2
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茂呂 和世 (2010)
Innate production of T[H]2 cytokines by adipose tissue-associated c-Kit[+]Sca-1[+] lymphoid cells -
April Price, Hong-Erh Liang, B. Sullivan, R. Reinhardt, C. Eisley, D. Erle, R. Locksley (2010)
Systemically dispersed innate IL-13–expressing cells in type 2 immunityProceedings of the National Academy of Sciences, 107
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Shona Wilson, F. Jones, H. Fofana, A. Landouré, G. Kimani, J. Mwatha, M. Sacko, B. Vennervald, D. Dunne (2013)
A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophilsParasite Immunology, 35
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Lucie Roussel, M. Erard, C. Cayrol, J. Girard (2008)
Molecular mimicry between IL‐33 and KSHV for attachment to chromatin through the H2A–H2B acidic pocketEMBO reports, 9
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H. Kouzaki, K. Iijima, Takao Kobayashi, S. O’Grady, H. Kita (2011)
The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type ResponsesThe Journal of Immunology, 186
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K. Bulek, S. Swaidani, J. Qin, Y. Lu, M. Gulen, T. Herjan, B. Min, R. Kastelein, M. Aronica, M. Kosz-Vnenchak, Xia Li (2009)
The Essential Role of Single Ig IL-1 Receptor-Related Molecule/Toll IL-1R8 in Regulation of Th2 Immune Response1The Journal of Immunology, 182
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Su-en Tang, Heqing Huang, F. Hu, W. Zhou, Jianping Guo, Hui-Rong Jiang, R. Mu, Zhanguo Li (2013)
Increased IL-33 in Synovial Fluid and Paired Serum Is Associated with Disease Activity and Autoantibodies in Rheumatoid ArthritisClinical and Developmental Immunology, 2013
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This study uses T reg cell-specific deletion of ST2 to provide definitive evidence for the important role of IL-33 in tissue T reg cell homeostasis and effective muscle repair -
J. Hoogerwerf, M. Leendertse, C. Wieland, A. Vos, J. Boer, S. Florquin, T. Poll (2011)
Loss of suppression of tumorigenicity 2 (ST2) gene reverses sepsis-induced inhibition of lung host defense in mice.American journal of respiratory and critical care medicine, 183 7
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L. Jones, F. Roberts, M. Nickdel, F. Brombacher, A. McKenzie, F. Henriquez, J. Alexander, C. Roberts (2010)
IL‐33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondiiEuropean Journal of Immunology, 40
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Andreas Lingel, Thomas Weiss, M. Niebuhr, B. Pan, Brent Appleton, C. Wiesmann, J. Bazan, Wayne Fairbrother (2009)
Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes.Structure, 17 10
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IL-33 Exacerbates Periodontal Disease through Induction of RANKLJournal of Dental Research, 94
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Shinobu Tominaga (1989)
A putative protein of a growth specific cDNA from BALB/C‐3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptorFEBS Letters, 258
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Wei‐Yu Chen, Jaewoo Hong, Joseph Gannon, R. Kakkar, Richard Lee (2015)
Myocardial pressure overload induces systemic inflammation through endothelial cell IL-33Proceedings of the National Academy of Sciences, 112
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Changwei Li, Hongquan Li, Ziwei Jiang, Tian Zhang, Yue Wang, Zhiheng Li, Yelin Wu, S. Ji, S. Xiao, B. Ryffel, Katherine Radek, Z. Xia, Y. Lai (2014)
Interleukin-33 Increases Antibacterial Defense by Activation of Inducible Nitric Oxide Synthase in SkinPLoS Pathogens, 10
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- Publisher
- Springer Journals
- Copyright
- Copyright © 2016 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
- Subject
- Biomedicine; Biomedicine, general; Immunology
- ISSN
- 1474-1733
- eISSN
- 1474-1741
- DOI
- 10.1038/nri.2016.95
- Publisher site
- See Article on Publisher Site
Abstract
Broad expression in stromal and barrier tissue renders interleukin-33 (IL-33) a ubiquitous and crucial immune modulator that shapes type 1, type 2 and regulatory immune responses. Although lacking a secretion sequence and sequestered in the nucleus, IL-33 is released and processed into highly active forms by various proteases. IL-33 contributes to cytokine networks that not only control pathogen removal but also support tissue repair mediated by group 2 innate lymphoid cells and regulatory T cells. The role of IL-33 is expected to continue to expand, modulating both protective and pathological immune responses. Delivering or blocking IL-33 is emerging as a promising therapeutic strategy for maintaining immune homeostasis and protecting against infectious and inflammatory diseases.
Journal
Nature Reviews Immunology – Springer Journals
Published: Sep 19, 2016