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Genome-wide association study identifies five new schizophrenia loci

Genome-wide association study identifies five new schizophrenia loci resear ch highlights in the endoplasmic reticulum (ER) and can- a new β cell model not be secreted through the Golgi-mediated n ew from nPg The derivation of a human pancreatic beta cell exocytic pathway. Heon Yung Gee and col- line has been a heroic but elusive quest. Such leagues showed that this protein reached the c ell-to-cell spread of HiV permits ongoing replication despite antiretroviral therapy a line would be a valuable tool to study normal membrane after blocking ER-to-Golgi traffick- Sigal, A. et al. Nature 477, 95–98 (2011). beta cell function, model cell replacement ing in vitro. This transport route was medi- The authors propose a model to explain therapy for diabetes and use in drug screening. ated by inositol-requiring protein 1 (IRE-1), how an HIV reservoir can be maintained Now, Philippe Ravassard and his colleagues which activates the unfolded protein response even in the face of antiretroviral therapy, (J. Clin. Invest. 121, 3589–3597) finally (UPR). Using knockout and overexpression via cell-to-cell spread of the virus, which describe the derivation of functional beta cells. strategies in cultured cells, the authors found could result in multiple viral infections The authors used a sequential method, that GRASPs were required http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Medicine Springer Journals

Genome-wide association study identifies five new schizophrenia loci

Swami, Meera
Nature Medicine , Volume 17 (10) – Oct 1, 2011
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Genome-wide association study identifies five new schizophrenia loci

Abstract

resear ch highlights in the endoplasmic reticulum (ER) and can- a new β cell model not be secreted through the Golgi-mediated n ew from nPg The derivation of a human pancreatic beta cell exocytic pathway. Heon Yung Gee and col- line has been a heroic but elusive quest. Such leagues showed that this protein reached the c ell-to-cell spread of HiV permits ongoing replication despite antiretroviral therapy a line would be a valuable tool to study normal membrane after blocking ER-to-Golgi...
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Publisher
Springer Journals
Copyright
Copyright © Springer Nature America, Inc. 2011
Subject
Biomedicine; Biomedicine, general; Cancer Research; Metabolic Diseases; Infectious Diseases; Molecular Medicine; Neurosciences
ISSN
1078-8956
eISSN
1546-170X
DOI
10.1038/nm.2523
Publisher site
See Article on Publisher Site

Abstract

resear ch highlights in the endoplasmic reticulum (ER) and can- a new β cell model not be secreted through the Golgi-mediated n ew from nPg The derivation of a human pancreatic beta cell exocytic pathway. Heon Yung Gee and col- line has been a heroic but elusive quest. Such leagues showed that this protein reached the c ell-to-cell spread of HiV permits ongoing replication despite antiretroviral therapy a line would be a valuable tool to study normal membrane after blocking ER-to-Golgi traffick- Sigal, A. et al. Nature 477, 95–98 (2011). beta cell function, model cell replacement ing in vitro. This transport route was medi- The authors propose a model to explain therapy for diabetes and use in drug screening. ated by inositol-requiring protein 1 (IRE-1), how an HIV reservoir can be maintained Now, Philippe Ravassard and his colleagues which activates the unfolded protein response even in the face of antiretroviral therapy, (J. Clin. Invest. 121, 3589–3597) finally (UPR). Using knockout and overexpression via cell-to-cell spread of the virus, which describe the derivation of functional beta cells. strategies in cultured cells, the authors found could result in multiple viral infections The authors used a sequential method, that GRASPs were required

Journal

Nature Medicine – Springer Journals

Published: Oct 1, 2011

There are no references for this article.