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HEREDITARY STENOSIS OF THE AQUEDUCT OF SYLVIUS AS A CAUSE OF CONGENITAL HYDROCEPHALUS BY DONALD S. BICKERS, M.D.,1 and RAYMOND D. ADAMS, M.D.2 CONGENITAL hydrocephalus occurs with sufficient frequency to be of lasting interest to clinicians and pathologists alike. According to Kovats [20] the incidence of this condition is about 1 in every 1,500 births. A large number of pathologically verified cases have been reported. Usually the mechanism of the hydrocephalus has been a demonstrable obstruction of the cerebrospinal fluid circulation. In some cases the obstruction was in the aqueduct of Sylvius, and in others at the foramens of Luschka and Magendie; in a third group an Arnold-Chiari malformation has resulted in displacement of the foramens of Luschka and Magendie into the cervical spinal canal and in a fourth group the subarachnoid spaces at the base of the brain was obliterated. The relative frequency of these different types of hydrocephalus is not known. Dandy [8] stated that about half of his congenital cases were due to stenosis of the aqueduct, but in our own material hydrocephalus with the Arnold-Chiari malformation is consider- ably more frequent than aqueductal stenosis. The most commonly demonstrated aetiology of congenital hydro- cephalus has been
Brain – Oxford University Press
Published: Jun 1, 1949
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