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Mammary duct proliferation in the elderly. A histopathologic study

Mammary duct proliferation in the elderly. A histopathologic study Both breasts of women over 70 years of age dying from causes other than mammary cancer were studied microscopically at autopsy by multiple step sections. Intense focal intraductal proliferative activity was characteristic of almost half of the breasts of women in this age group. Proliferative intraductal changes tended to be bilateral and were frequently associated with adenosis and intraductal papillomas. Four cases (5.7%) showed intraductal carcinoma, and, in one of these (1.4%), there was a focus of microinvasion. All four cases showed both benign and atypical hyperplastic lesions in other areas of the breast. It is concluded that occult infiltrating breast carcinoma, unlike occult prostatic carcinoma, is an infrequent lesion in the elderly. Intraductal carcinoma, while somewhat more common, is unlikely to eventuate in clinical malignancy within the life span of these patients. Intraductal hyperplasia appears to be a common finding in the elderly and need not be viewed with alarm. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Wiley

Mammary duct proliferation in the elderly. A histopathologic study

Kramer, William M.; Rush, Benjamin F.
Cancer , Volume 31 (1) – Jan 1, 1973
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References (10)

Publisher
Wiley
Copyright
Copyright © 1973 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0008-543X
eISSN
1097-0142
DOI
10.1002/1097-0142(197301)31:1<130::AID-CNCR2820310117>3.0.CO;2-N
Publisher site
See Article on Publisher Site

Abstract

Both breasts of women over 70 years of age dying from causes other than mammary cancer were studied microscopically at autopsy by multiple step sections. Intense focal intraductal proliferative activity was characteristic of almost half of the breasts of women in this age group. Proliferative intraductal changes tended to be bilateral and were frequently associated with adenosis and intraductal papillomas. Four cases (5.7%) showed intraductal carcinoma, and, in one of these (1.4%), there was a focus of microinvasion. All four cases showed both benign and atypical hyperplastic lesions in other areas of the breast. It is concluded that occult infiltrating breast carcinoma, unlike occult prostatic carcinoma, is an infrequent lesion in the elderly. Intraductal carcinoma, while somewhat more common, is unlikely to eventuate in clinical malignancy within the life span of these patients. Intraductal hyperplasia appears to be a common finding in the elderly and need not be viewed with alarm.

Journal

Cancer – Wiley

Published: Jan 1, 1973

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