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- Publisher
- Oxford University Press
- Copyright
- © 1995 British Society for Antimicrobial Chemotherapy
- ISSN
- 0305-7453
- eISSN
- 1460-2091
- DOI
- 10.1093/jac/36.4.717
- Publisher site
- See Article on Publisher Site
Abstract
Abstract We studied the enteric absorption of ciprofloxacin immediately following major abdominal surgery to determine if this drug could replace parenteral agents. Nine critically ill subjects received ciprofloxacin, 750 mg, every 12 h for 48 h via nasogastric tube. Drug concentrations were measured after the first and fourth doses. There was insignificant absorption after the initial dose, Cmax = 0.6 ± 0.6 (mg/L) and AUCo-12 = 3.5 ± 3.2 (mg.h/L). Unfortunately, serum ciprofloxacin concentrations were also minimally detectable in three of nine subjects after the fourth dose. Enteric absorption of ciprofloxacin, therefore, was erratic and unpredictable in critically ill patients following major abdominal surgery. This content is only available as a PDF. © 1995 British Society for Antimicrobial Chemotherapy
Journal
Journal of Antimicrobial Chemotherapy – Oxford University Press
Published: Oct 1, 1995