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Effect of silane treatment and different resin compositions on biological properties of bioactive bone cement containing apatite‐wollastonite glass ceramic powder

Effect of silane treatment and different resin compositions on biological properties of bioactive... In methylmethacrylate (MMA)‐based cements containing bioactive particles, polymethylmetacrylate (PMMA) is known to suppress the bioactivity of Bioglass® and apatite‐wollastonite glass ceramic (AW‐GC). Little is known about the effect of different silane treatment methods on the bioactivity of AW‐GC. MMA‐based cement plates containing dry silanated AW‐GC particles and PMMA particles of different molecular weights (12,000–900,000) were immersed in simulated body fluid (SBF). Cements containing PMMA particles of high molecular weight formed an apatite layer on the surface after 24 h. Using PMMA particles with a molecular weight of 60,000 and AW‐GC particles silanated with different methods (dry method vs. slurry method), cement plates were made and immersed in SBF. Only cement plates containing dry silanated AW‐GC particles showed apatite formation in SBF after 3 days. In vivo implantation in rat tibias of MMA‐based cement containing dry silanated AW‐GC particles and PMMA particles (molecular weight 900,000) demonstrated an affinity index of 32.1 ± 15.8% after 8 weeks of implantation compared to 89.4 ± 10.7% achieved by bisphenol‐A‐glycidyl methacrylate based cement containing the same bioactive powder. By using a dry method of silane treatment and high molecular weight PMMA particles, the bioactivity of cement based on MMA monomer was achieved; but further effort is needed to improve the mechanical properties of the composite. © 1999 John Wiley & Sons, Inc. J Biomed Mater Res, 47, 336–344, 1999. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Biomedical Materials Research Part A Wiley

Effect of silane treatment and different resin compositions on biological properties of bioactive bone cement containing apatite‐wollastonite glass ceramic powder

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References (31)

Publisher
Wiley
Copyright
Copyright © 1999 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1549-3296
eISSN
1552-4965
DOI
10.1002/(SICI)1097-4636(19991205)47:3<336::AID-JBM7>3.0.CO;2-O
Publisher site
See Article on Publisher Site

Abstract

In methylmethacrylate (MMA)‐based cements containing bioactive particles, polymethylmetacrylate (PMMA) is known to suppress the bioactivity of Bioglass® and apatite‐wollastonite glass ceramic (AW‐GC). Little is known about the effect of different silane treatment methods on the bioactivity of AW‐GC. MMA‐based cement plates containing dry silanated AW‐GC particles and PMMA particles of different molecular weights (12,000–900,000) were immersed in simulated body fluid (SBF). Cements containing PMMA particles of high molecular weight formed an apatite layer on the surface after 24 h. Using PMMA particles with a molecular weight of 60,000 and AW‐GC particles silanated with different methods (dry method vs. slurry method), cement plates were made and immersed in SBF. Only cement plates containing dry silanated AW‐GC particles showed apatite formation in SBF after 3 days. In vivo implantation in rat tibias of MMA‐based cement containing dry silanated AW‐GC particles and PMMA particles (molecular weight 900,000) demonstrated an affinity index of 32.1 ± 15.8% after 8 weeks of implantation compared to 89.4 ± 10.7% achieved by bisphenol‐A‐glycidyl methacrylate based cement containing the same bioactive powder. By using a dry method of silane treatment and high molecular weight PMMA particles, the bioactivity of cement based on MMA monomer was achieved; but further effort is needed to improve the mechanical properties of the composite. © 1999 John Wiley & Sons, Inc. J Biomed Mater Res, 47, 336–344, 1999.

Journal

Journal of Biomedical Materials Research Part A – Wiley

Published: May 5, 1999

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