Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development

The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during... Downloaded from genesdev.cshlp.org on September 30, 2021 - Published by Cold Spring Harbor Laboratory Press The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development 1,2 1,4 1,4 1 2 Eva Reissmann, Henrik Jörnvall, Andries Blokzijl, Olov Andersson, Chenbei Chang, 3 3 1,5 2 Gabriella Minchiotti, M. Graziella Persico, Carlos F. Ibáñez, and Ali H. Brivanlou Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, S-17177 Stockholm, Sweden; Laboratory of Molecular Vertebrate Embryology, The Rockefeller University, New York, New York 10021-6399, USA; International Institute of Genetics andBiophysics, CNR, 80125 Naples, Italy Nodal proteins have crucial roles in mesendoderm formation and left–right patterning during vertebrate development. The molecular mechanisms of signal transduction by Nodal and related ligands, however, are not fully understood. In this paper, we present biochemical and functional evidence that the orphan type I serine/threonine kinase receptor ALK7 acts as a receptor for mouse Nodal and Xenopus Nodal-related 1 (Xnr1). Receptor reconstitution experiments indicate that ALK7 collaborates with ActRIIB to confer responsiveness to Xnr1 and Nodal. Both receptors can independently bind Xnr1. In addition, Cripto, an extracellular protein genetically implicated in Nodal signaling, can independently interact with both Xnr1 and ALK7, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development

Download PDF
14 pages

Loading next page...
 
/lp/unpaywall/the-orphan-receptor-alk7-and-the-activin-receptor-alk4-mediate-nh4F2YwQkO

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.201801
Publisher site
See Article on Publisher Site

Abstract

Downloaded from genesdev.cshlp.org on September 30, 2021 - Published by Cold Spring Harbor Laboratory Press The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development 1,2 1,4 1,4 1 2 Eva Reissmann, Henrik Jörnvall, Andries Blokzijl, Olov Andersson, Chenbei Chang, 3 3 1,5 2 Gabriella Minchiotti, M. Graziella Persico, Carlos F. Ibáñez, and Ali H. Brivanlou Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, S-17177 Stockholm, Sweden; Laboratory of Molecular Vertebrate Embryology, The Rockefeller University, New York, New York 10021-6399, USA; International Institute of Genetics andBiophysics, CNR, 80125 Naples, Italy Nodal proteins have crucial roles in mesendoderm formation and left–right patterning during vertebrate development. The molecular mechanisms of signal transduction by Nodal and related ligands, however, are not fully understood. In this paper, we present biochemical and functional evidence that the orphan type I serine/threonine kinase receptor ALK7 acts as a receptor for mouse Nodal and Xenopus Nodal-related 1 (Xnr1). Receptor reconstitution experiments indicate that ALK7 collaborates with ActRIIB to confer responsiveness to Xnr1 and Nodal. Both receptors can independently bind Xnr1. In addition, Cripto, an extracellular protein genetically implicated in Nodal signaling, can independently interact with both Xnr1 and ALK7,

Journal

Genes & Development – Unpaywall

Published: Aug 1, 2001

There are no references for this article.