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Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma

Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma †‡ †§ § § § Jean S. Campbell* , Steven D. Hughes , Debra G. Gilbertson , Thomas E. Palmer , Matthew S. Holdren* , § § § Aaron C. Haran , Melissa M. Odell*, Renay L. Bauer*, Hong-Ping Ren , Harald S. Haugen , Matthew M. Yeh*, and Nelson Fausto* *Department of Pathology, University of Washington, Seattle, WA 98115; and ZymoGenetics, Inc., 1201 Eastlake Avenue East, Seattle, WA 98102 Communicated by Edwin G. Krebs, University of Washington School of Medicine, Seattle, WA, January 19, 2005 (received for review October 15, 2004) Members of the platelet-derived growth factor (PDGF) ligand tion, and the overexpression of this receptor is also associated family are known to play important roles in wound healing and with liver fibrosis (20, 21). In vivo, PDGF-BB is a potent mitogen fibrotic disease. We show that both transient and stable expression for HSC and can also induce the synthesis of several ECM of PDGF-C results in the development of liver fibrosis consisting of components (22–24). Although TGF1 and PDGFR signaling the deposition of collagen in a pericellular and perivenular pattern pathways are critical to liver fibrosis, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Proceedings of the National Academy of Sciences Unpaywall

Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma

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Unpaywall
ISSN
0027-8424
DOI
10.1073/pnas.0409722102
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Abstract

Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma †‡ †§ § § § Jean S. Campbell* , Steven D. Hughes , Debra G. Gilbertson , Thomas E. Palmer , Matthew S. Holdren* , § § § Aaron C. Haran , Melissa M. Odell*, Renay L. Bauer*, Hong-Ping Ren , Harald S. Haugen , Matthew M. Yeh*, and Nelson Fausto* *Department of Pathology, University of Washington, Seattle, WA 98115; and ZymoGenetics, Inc., 1201 Eastlake Avenue East, Seattle, WA 98102 Communicated by Edwin G. Krebs, University of Washington School of Medicine, Seattle, WA, January 19, 2005 (received for review October 15, 2004) Members of the platelet-derived growth factor (PDGF) ligand tion, and the overexpression of this receptor is also associated family are known to play important roles in wound healing and with liver fibrosis (20, 21). In vivo, PDGF-BB is a potent mitogen fibrotic disease. We show that both transient and stable expression for HSC and can also induce the synthesis of several ECM of PDGF-C results in the development of liver fibrosis consisting of components (22–24). Although TGF1 and PDGFR signaling the deposition of collagen in a pericellular and perivenular pattern pathways are critical to liver fibrosis,

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Proceedings of the National Academy of Sciences – Unpaywall

Published: Feb 22, 2005

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