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Rethinking the Roles of Inflammation in the Intracerebral Hemorrhage

Rethinking the Roles of Inflammation in the Intracerebral Hemorrhage Transl. Stroke Res. (2015) 6:339–341 DOI 10.1007/s12975-015-0402-1 COMMENTARY Rethinking the Roles of Inflammation in the Intracerebral Hemorrhage 1 1 Xiao-Yi Xiong & Qing-Wu Yang Received: 17 April 2015 /Accepted: 21 April 2015 /Published online: 5 May 2015 Springer Science+Business Media New York 2015 Blood in the vessels bleeds into the brain parenchyma resulting heme, iron, etc., into the perihematoma tissues [4, 9–11]. in the intracerebral hemorrhage (ICH) [1]. The direct mass Then, these components of hematoma immediately trigger effect of the rapidly formed hematoma causes the brain dam- the inflammatory responses, which subsequently recruit age, which leads to neurologic deficit. Thus, clearing the he- and activate most inflammatory cells involved in the brain matoma may be beneficial to the patient with ICH. However, inflammatory injury. For example, the activated resident the Surgical Trial in Intracerebral Hemorrhage (STICH) trial microglia and astrocyte, releasing a large amount of pro- showed no overall benefit from early hematoma evacuation inflammatory cytokines such as interleukin (IL)-6, compared to initial conservative treatment [2]. Therefore, the TNF-α,andIL-1β, are in response to the blood compo- secondary brain injury caused by the metabolic products or the nents implicated in the initial brain injury after ICH [1, 7]. components http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Translational Stroke Research Springer Journals

Rethinking the Roles of Inflammation in the Intracerebral Hemorrhage

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References (39)

Publisher
Springer Journals
Copyright
Copyright © 2015 by Springer Science+Business Media New York
Subject
Biomedicine; Neurosciences; Neurology; Cardiology; Neurosurgery; Vascular Surgery
ISSN
1868-4483
eISSN
1868-601X
DOI
10.1007/s12975-015-0402-1
pmid
25940771
Publisher site
See Article on Publisher Site

Abstract

Transl. Stroke Res. (2015) 6:339–341 DOI 10.1007/s12975-015-0402-1 COMMENTARY Rethinking the Roles of Inflammation in the Intracerebral Hemorrhage 1 1 Xiao-Yi Xiong & Qing-Wu Yang Received: 17 April 2015 /Accepted: 21 April 2015 /Published online: 5 May 2015 Springer Science+Business Media New York 2015 Blood in the vessels bleeds into the brain parenchyma resulting heme, iron, etc., into the perihematoma tissues [4, 9–11]. in the intracerebral hemorrhage (ICH) [1]. The direct mass Then, these components of hematoma immediately trigger effect of the rapidly formed hematoma causes the brain dam- the inflammatory responses, which subsequently recruit age, which leads to neurologic deficit. Thus, clearing the he- and activate most inflammatory cells involved in the brain matoma may be beneficial to the patient with ICH. However, inflammatory injury. For example, the activated resident the Surgical Trial in Intracerebral Hemorrhage (STICH) trial microglia and astrocyte, releasing a large amount of pro- showed no overall benefit from early hematoma evacuation inflammatory cytokines such as interleukin (IL)-6, compared to initial conservative treatment [2]. Therefore, the TNF-α,andIL-1β, are in response to the blood compo- secondary brain injury caused by the metabolic products or the nents implicated in the initial brain injury after ICH [1, 7]. components

Journal

Translational Stroke Research – Springer Journals

Published: May 5, 2015

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