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References (62)
-
Renubala Sharma, M. Vinayak (2012)
Antioxidant α-tocopherol checks lymphoma promotion via regulation of expression of protein kinase C-α and c-Myc genes and glycolytic metabolismLeukemia & Lymphoma, 53
-
C. Kandaswami, Lung-Ta Lee, P. Lee, J. Hwang, F. Ke, Yingran Huang, Ming‐ting Lee (2005)
The antitumor activities of flavonoids.In vivo, 19 5
-
Priyanka Batra, A. Sharma (2013)
Anti-cancer potential of flavonoids: recent trends and future perspectives3 Biotech, 3
-
Tae-Jin Lee, O. Kim, Y. Kim, J. Lim, Shin Kim, Jong-Wook Park, T. Kwon (2006)
Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells.Cancer letters, 240 2
-
P. Dehn, C. White, D. Conners, G. Shipkey, T. Cumbo (2004)
Characterization of the human hepatocellular carcinoma (HEPG2) cell line as an in vitro model for cadmium toxicity studiesIn Vitro Cellular & Developmental Biology - Animal, 40
-
Adam Hayashi, Aric Gillen, James Lott (2000)
Effects of daily oral administration of quercetin chalcone and modified citrus pectin on implanted colon-25 tumor growth in Balb-c mice.Alternative medicine review : a journal of clinical therapeutic, 5 6
-
Trang‐Tiau Wu, Y. Hsieh, Y. Hsieh, Jer‐Yuh Liu (2008)
Reduction of PKCα decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinomaJournal of Cellular Biochemistry, 103
-
D. Ferry, A. Smith, J. Malkhandi, D. Fyfe, P. deTakats, D. Anderson, J. Baker, D. Kerr (1996)
Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition.Clinical cancer research : an official journal of the American Association for Cancer Research, 2 4
-
Samarjit Das, D. Bedja, Nathaniel Campbell, Brittany Dunkerly, Venugopal Chenna, A. Maitra, C. Steenbergen (2014)
miR-181c Regulates the Mitochondrial Genome, Bioenergetics, and Propensity for Heart Failure In VivoPLoS ONE, 9
-
Sudha Mishra, M. Vinayak (2014)
Ellagic acid inhibits PKC signaling by improving antioxidant defense system in murine T cell lymphomaMolecular Biology Reports, 41
-
B. Geering, P. Cutillas, Gemma Nock, S. Gharbi, B. Vanhaesebroeck (2007)
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimersProceedings of the National Academy of Sciences, 104
-
A. Maurya, M. Vinayak (2015)
Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer preventionTumor Biology, 36
-
A. Ardeshirylajimi, M. Soleimani, S. Hosseinkhani, K. Parivar, P. Yaghmaei (2014)
A Comparative Study of Osteogenic Differentiation Human Induced Pluripotent Stem Cells and Adipose Tissue Derived Mesenchymal Stem CellsCell Journal (Yakhteh), 16
-
E. Miyashita, Bin Yang, K. Lam, D. Crawford, D. Thorley-Lawson (1995)
A novel form of Epstein-Barr virus latency in normal B cells in vivoCell, 80
-
Kazufumi Suzuki, H. Matsubara (2011)
Recent Advances in p53 Research and Cancer TreatmentJournal of Biomedicine and Biotechnology, 2011
-
K-C Choi, W. Chung, J. Kwon, J. Yu, Y. Jang, S. Park, S.Y. Lee, J-C Lee (2010)
Inhibitory effects of quercetin on aflatoxin B1-induced hepatic damage in mice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48 10
-
A. Ristimäki, A. Sivula, J. Lundin, M. Lundin, T. Salminen, C. Haglund, H. Joensuu, J. Isola (2002)
Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer.Cancer research, 62 3
-
A. Roe, J. Snawder, R. Benson, D. Roberts, D. Casciano (1993)
HepG2 cells: an in vitro model for P450-dependent metabolism of acetaminophen.Biochemical and biophysical research communications, 190 1
-
Wen-Sheng Wu (2007)
The signaling mechanism of ROS in tumor progressionCancer and Metastasis Reviews, 25
-
O Konopatskaya, AW Poole (2010)
Protein kinase C alpha: disease regulator and therapeutic targetTrends Pharmacol Sci, 31
-
Laxmidhar Das, M. Vinayak (2014)
Long Term Effect of Curcumin in Regulation of Glycolytic Pathway and Angiogenesis via Modulation of Stress Activated Genes in Prevention of CancerPLoS ONE, 9
-
A. Villanueva, B. Mínguez, A. Forner, M. Reig, J. Llovet (2010)
Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy.Annual review of medicine, 61
-
(2015)
Mol Biol Rep -
J. Young, S. Nielsen, J. Haraldsdóttir, B. Daneshvar, S. Lauridsen, P. Knuthsen, A. Crozier, B. Sandström, L. Dragsted, J. Kumpulainen, J. Salonen (1999)
Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status.The American journal of clinical nutrition, 69 1
-
Stephen Smith, M. Enge, Wenjie Bao, M. Thullberg, Tânia Costa, Helene Olofsson, B. Gashi, G. Selivanova, S. Strömblad (2012)
Protein Kinase Cα (PKCα) Regulates p53 Localization and Melanoma Cell Survival Downstream of Integrin αv in Three-dimensional Collagen and in Vivo*The Journal of Biological Chemistry, 287
-
I. Porębska, E. Wyrodek, M. Kosacka, J. Adamiak, R. Jankowska, A. Harłozińska-Szmyrka (2006)
Apoptotic markers p53, Bcl-2 and Bax in primary lung cancer.In vivo, 20 5
-
M. Caino, J. Meshki, M. Kazanietz (2009)
Hallmarks for senescence in carcinogenesis: novel signaling playersApoptosis, 14
-
D. Boulton, U. Walle, T. Walle (1999)
Fate of the Flavonoid Quercetin in Human Cell Lines: Chemical Instability and MetabolismJournal of Pharmacy and Pharmacology, 51
-
A Ristimaki, A Sivula, J Lundin, M Lundin, T Salminen, C Haglund, H Joensuu, J Isola (2002)
Significance of elevated cyclooxygenase-2 expression in breast cancerCancer Res, 62
-
Cyril Sobolewski, C. Cerella, M. Dicato, L. Ghibelli, M. Diederich (2010)
The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human MalignanciesInternational Journal of Cell Biology, 2010
-
D. Trachootham, Weiqin Lu, Marcia Ogasawara, Rivera-Del Nilsa, Peng Huang (2008)
Redox regulation of cell survival.Antioxidants & redox signaling, 10 8
-
W. Qian, M. Nishikawa, A. Haque, Masaki Hirose, M. Mashimo, E. Sato, M. Inoue (2005)
Mitochondrial density determines the cellular sensitivity to cisplatin-induced cell death.American journal of physiology. Cell physiology, 289 6
-
M. Shanmugam, Radhamani Kannaiyan, G. Sethi (2011)
Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of CancerNutrition and Cancer, 63
-
C. Giorgi, Chiara Agnoletto, C. Baldini, Angela Bononi, M. Bonora, S. Marchi, S. Missiroli, S. Patergnani, Federica Poletti, A. Rimessi, B. Zavan, P. Pinton (2010)
Redox control of protein kinase C: cell- and disease-specific aspects.Antioxidants & redox signaling, 13 7
-
A. Maurya, M. Vinayak (2015)
Quercetin Regresses Dalton's Lymphoma Growth via Suppression of PI3K/AKT Signaling Leading to Upregulation of p53 and Decrease in Energy MetabolismNutrition and Cancer, 67
-
E. Walker, M. Pacold, O. Perisic, L. Stephens, P. Hawkins, M. Wymann, Roger Williams (2000)
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.Molecular cell, 6 4
-
Hua Yao, Weizhen Xu, Xianglin Shi, Zhuo Zhang (2011)
Dietary Flavonoids as Cancer Prevention AgentsJournal of Environmental Science and Health, Part C, 29
-
M. Harwood, B. Danielewska-Nikiel, J. Borzelleca, G. Flamm, G. Williams, T. Lines (2007)
A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 45 11
-
O. Konopatskaya, A. Poole (2010)
Protein kinase Cα: disease regulator and therapeutic targetTrends in Pharmacological Sciences, 31
-
Venus Sosa, T. Moliné, R. Somoza, R. Paciucci, H. Kondoh, M. Lleonart (2013)
Oxidative stress and cancer: An overviewAgeing Research Reviews, 12
-
Sudha Mishra, M. Vinayak (2011)
Anti-carcinogenic action of ellagic acid mediated via modulation of oxidative stress regulated genes in Dalton lymphoma bearing miceLeukemia & Lymphoma, 52
-
B. Vanhaesebroeck, J. Guillermet-Guibert, M. Graupera, B. Bilanges (2010)
The emerging mechanisms of isoform-specific PI3K signallingNature Reviews Molecular Cell Biology, 11
-
C. Sherr (2004)
Principles of Tumor SuppressionCell, 116
-
K. Subbaramaiah, N. Altorki, W. Chung, J. Mestre, Anu Sampat, A. Dannenberg (1999)
Inhibition of Cyclooxygenase-2 Gene Expression by p53*The Journal of Biological Chemistry, 274
-
Nibha Verma, M. Vinayak (2008)
Effect of Terminalia arjuna on antioxidant defense system in cancerMolecular Biology Reports, 36
-
Chi‐Hao Wu, Cheng-Feng Wu, Hsiao-wen Huang, Ya-Chien Jao, G. Yen (2009)
Naturally occurring flavonoids attenuate high glucose-induced expression of proinflammatory cytokines in human monocytic THP-1 cells.Molecular nutrition & food research, 53 8
-
P. Secchiero, E. Barbarotto, A. Gonelli, M. Tiribelli, Carlotta Zerbinati, C. Celeghini, C. Agostinelli, S. Pileri, G. Zauli (2005)
Potential pathogenetic implications of cyclooxygenase-2 overexpression in B chronic lymphoid leukemia cells.The American journal of pathology, 167 6
-
A. Raza, G. Sood (2014)
Hepatocellular carcinoma review: current treatment, and evidence-based medicine.World journal of gastroenterology, 20 15
-
M. Haghiac, T. Walle (2005)
Quercetin Induces Necrosis and Apoptosis in SCC-9 Oral Cancer CellsNutrition and Cancer, 53
-
Miyashita Toshiyuki, John Reed (1995)
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneCell, 80
-
C. Paulsen, Kate Carroll (2010)
Orchestrating redox signaling networks through regulatory cysteine switches.ACS chemical biology, 5 1
-
D. Trachootham, J. Alexandre, Peng Huang (2009)
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?Nature Reviews Drug Discovery, 8
-
L. Goya, R. Mateos, L. Bravo (2007)
Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cellsEuropean Journal of Nutrition, 46
-
Yan-jie Zhao, Q. Ju, Guan-Cheng Li (2013)
Tumor markers for hepatocellular carcinomaMolecular and Clinical Oncology, 1
-
Zhijun Sun, Gang Chen, Xiang Hu, Wei Zhang, Yang Liu, Lingxin Zhu, Qian Zhou, Yi-Fang Zhao (2010)
Activation of PI3K/Akt/IKK-α/NF-κB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetinApoptosis, 15
-
K. O'Leary, A. Day, P. Needs, F. Mellon, N. O'Brien, G. Williamson (2003)
Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism.Biochemical pharmacology, 65 3
-
T. Miyashita, S. Krajewski, M. Krajewska, H. Wang, H. Lin, D. Liebermann, B. Hoffman, John Reed (1994)
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.Oncogene, 9 6
-
Se-Kyoung Lee, A. Shehzad, Jae‐Chang Jung, J. Sonn, Jae-Tae Lee, Jeen-Woo Park, Young-Sup Lee (2012)
Protein kinase Cα protects against multidrug resistance in human colon cancer cellsMolecules and Cells, 34
-
L. Gamet-Payrastre, S. Manenti, M. Gratacap, J. Tulliez, H. Chap, B. Payrastre (1999)
Flavonoids and the inhibition of PKC and PI 3-kinase.General pharmacology, 32 3
-
R. Gopalakrishna, U. Gundimeda (2002)
Antioxidant regulation of protein kinase C in cancer prevention.The Journal of nutrition, 132 12
-
Sudha Mishra, M. Vinayak (2012)
Ellagic acid checks lymphoma promotion via regulation of PKC signaling pathwayMolecular Biology Reports, 40
-
B. Cohen, M. Yoakim, H. Piwnica-Worms, T. Roberts, B. Schaffhausen (1990)
Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity.Proceedings of the National Academy of Sciences of the United States of America, 87
- Publisher
- Springer Journals
- Copyright
- Copyright © 2015 by Springer Science+Business Media Dordrecht
- Subject
- Life Sciences; Animal Biochemistry; Animal Anatomy / Morphology / Histology
- ISSN
- 0301-4851
- eISSN
- 1573-4978
- DOI
- 10.1007/s11033-015-3921-7
- pmid
- 26311153
- Publisher site
- See Article on Publisher Site
Abstract
Protein kinase C (PKC) is a key regulator of cell growth and differentiation in mammalian cells and hyperactivation of PKC is believed to play an important role in tumor progression. PKC is downstream to signaling protein of phosphatidylinositol 3-Kinase (PI3K), a known up-regulator of cell proliferation and survival. Accumulation of reactive oxygen species (ROS) triggers oxidative stress in the tumor microenvironment, leading to the hyperactivation of various oxidative stress-stimulated signaling molecules. Quercetin (QUE) is a naturally occurring dietary flavonoid having antioxidant properties. QUE is reported to show antitumor activity both in vitro and in vivo; however, the molecular mechanism is yet to be thoroughly explored. HepG2 cells display cellular functions similar to the normal hepatocytes with high degree of morphological and functional differentiation, therefore HepG2 cell line is chosen as the suitable model for drug targeting. Present study is aimed to establish the signaling pathway involved in the anticarcinogenic action of QUE in HepG2 cell line. HepG2 cells were treated with different doses of QUE. Protein level and gene expression were analysed by Western blotting and RT-PCR, respectively. PKC activity was measured by non-radioactive-tagged phosphorylation. Results showed downregulation of expression of PI3K, PKC, COX-2 and ROS caused by QUE. Additionally, QUE enhanced the expression of p53 and BAX in HepG2 cells. Overall, results of the current study suggested that QUE elicited anticarcinogenic action by upregulation of p53 and BAX in HepG2 cells via downregulation of ROS, PKC, PI3K and COX-2, confirming our earlier report on the animal model.
Journal
Molecular Biology Reports – Springer Journals
Published: Aug 27, 2015