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Benefits and Risks of Tight Glucose Control in Critically Ill Adults

Benefits and Risks of Tight Glucose Control in Critically Ill Adults CLINICIAN’S CORNER CARING FOR THE CRITICALLY ILL PATIENT Benefits and Risks of Tight Glucose Control in Critically Ill Adults A Meta-analysis Renda Soylemez Wiener, MD, MPH Context The American Diabetes Association and Surviving Sepsis Campaign recom- Daniel C. Wiener, MD mend tight glucose control in critically ill patients based largely on 1 trial that shows decreased mortality in a surgical intensive care unit. Because similar studies report con- Robin J. Larson, MD, MPH flicting results and tight glucose control can cause dangerous hypoglycemia, the data underlying this recommendation should be critically evaluated. N 2001 VAN DEN BERGHE ET AL PUB- lished a randomized controlled trial Objective To evaluate benefits and risks of tight glucose control vs usual care in criti- of critically ill surgical patients cally ill adult patients. Ishowing that tight glucose con- Data Sources MEDLINE (1950-2008), the Cochrane Library, clinical trial registries, trol reduced hospital mortality by one- reference lists, and abstracts from conferences from both the American Thoracic So- third. Since the greatest decrease in ciety (2001-2008) and the Society of Critical Care Medicine (2004-2008). deaths occurred in the subgroup of pa- Study Selection We searched for studies in any language in which adult intensive tients http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Benefits and Risks of Tight Glucose Control in Critically Ill Adults

Wiener, Renda Soylemez; Wiener, Daniel C.; Larson, Robin J.
JAMA , Volume 300 (8) – Aug 27, 2008
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References (64)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.300.8.933
pmid
18728267
Publisher site
See Article on Publisher Site

Abstract

CLINICIAN’S CORNER CARING FOR THE CRITICALLY ILL PATIENT Benefits and Risks of Tight Glucose Control in Critically Ill Adults A Meta-analysis Renda Soylemez Wiener, MD, MPH Context The American Diabetes Association and Surviving Sepsis Campaign recom- Daniel C. Wiener, MD mend tight glucose control in critically ill patients based largely on 1 trial that shows decreased mortality in a surgical intensive care unit. Because similar studies report con- Robin J. Larson, MD, MPH flicting results and tight glucose control can cause dangerous hypoglycemia, the data underlying this recommendation should be critically evaluated. N 2001 VAN DEN BERGHE ET AL PUB- lished a randomized controlled trial Objective To evaluate benefits and risks of tight glucose control vs usual care in criti- of critically ill surgical patients cally ill adult patients. Ishowing that tight glucose con- Data Sources MEDLINE (1950-2008), the Cochrane Library, clinical trial registries, trol reduced hospital mortality by one- reference lists, and abstracts from conferences from both the American Thoracic So- third. Since the greatest decrease in ciety (2001-2008) and the Society of Critical Care Medicine (2004-2008). deaths occurred in the subgroup of pa- Study Selection We searched for studies in any language in which adult intensive tients

Journal

JAMA – American Medical Association

Published: Aug 27, 2008

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