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Is 472G/A catechol-O-methyl-transferase

Is 472G/A catechol-O-methyl-transferase Original article 267 Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder? a b Elias Zintzaras and Nikolaos Sakelaridis Objectives Case–control studies relating 472G/A Caucasians [OR = 1.26 (0.93–1.69) and (P = 0.24, catechol-O-methyl-transferase polymorphism with the risk I = 28%)] existed. The genotype differences for the of developing panic disorder showed inconclusive or homozygotes, the recessive and dominant models for contradictory results. To shed some light on these results a allele G produced the same overall pattern like the allele meta-analysis of all available case–control studies was contrast in terms of association and heterogeneity. No conducted. differential magnitude of effect in large versus small studies for each polymorphism investigating was found. The cumulative meta-analysis showed an increase in OR Methods We searched PubMed database for English- languages case–control studies using the key words: as evidence accumulated. Catechol-O-methyl-transferase and panic. Case–control studies that determined the distribution of 472G/A Conclusions No conclusive evidence showing that genotypes in cases with primary and predominant panic 472G/A polymorphism is a reliable marker for panic disorder, and in controls free of psychiatric disorders were disorder was found; moreover, large heterogeneity eligible for inclusion in the meta-analysis. The pooled risk between studies existed. Large and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychiatric Genetics Wolters Kluwer Health

Is 472G/A catechol-O-methyl-transferase

Sakelaridis, Nikolaos
Psychiatric Genetics , Volume 17 (5) – Oct 1, 2007
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ISSN
0955-8829
eISSN
1473-5873
DOI
10.1097/YPG.0b013e3280d6472e
pmid
17728665
Publisher site
See Article on Publisher Site

Abstract

Original article 267 Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder? a b Elias Zintzaras and Nikolaos Sakelaridis Objectives Case–control studies relating 472G/A Caucasians [OR = 1.26 (0.93–1.69) and (P = 0.24, catechol-O-methyl-transferase polymorphism with the risk I = 28%)] existed. The genotype differences for the of developing panic disorder showed inconclusive or homozygotes, the recessive and dominant models for contradictory results. To shed some light on these results a allele G produced the same overall pattern like the allele meta-analysis of all available case–control studies was contrast in terms of association and heterogeneity. No conducted. differential magnitude of effect in large versus small studies for each polymorphism investigating was found. The cumulative meta-analysis showed an increase in OR Methods We searched PubMed database for English- languages case–control studies using the key words: as evidence accumulated. Catechol-O-methyl-transferase and panic. Case–control studies that determined the distribution of 472G/A Conclusions No conclusive evidence showing that genotypes in cases with primary and predominant panic 472G/A polymorphism is a reliable marker for panic disorder, and in controls free of psychiatric disorders were disorder was found; moreover, large heterogeneity eligible for inclusion in the meta-analysis. The pooled risk between studies existed. Large and

Journal

Psychiatric Genetics – Wolters Kluwer Health

Published: Oct 1, 2007

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