Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/foxp3-not-just-for-regulatory-t-cells-anymore-ovuYzrbJ4J
References (26)
-
J. Tsang, N. Câmara, E. Eren, H. Schneider, C. Rudd, G. Lombardi, R. Lechler (2006)
Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cellsJournal of Leukocyte Biology, 80
-
Jun Wang, A. Ioan-Facsinay, Ellen I. H. van der Voort, T. Huizinga, R. Toes (2007)
Transient expression of FOXP3 in human activated nonregulatory CD4+ T cellsEuropean Journal of Immunology, 37
-
L. Schubert, E. Jeffery, Yi Zhang, F. Ramsdell, S. Ziegler (2001)
Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation*The Journal of Biological Chemistry, 276
-
Yongqin Wu, M. Borde, V. Heissmeyer, M. Feuerer, A. Lapan, J. Stroud, D. Bates, Liang Guo, A. Han, S. Ziegler, D. Mathis, C. Benoist, Lin Chen, A. Rao (2006)
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFATCell, 126
-
Hori Hori, Nomura Nomura, Sakaguchi Sakaguchi (2003)
Control of regulatory T cell development by the transcription factor FoxP3.Science, 299
-
Allan Allan, Passerini Passerini, Bacchetta Bacchetta, Crellin Crellin, Da Da, Orban Orban, Ziegler Ziegler, Roncarolo Roncarolo (2005)
The role of FOXP3, and an isoform lacking exon 2, in the generation of human CD4+ T regulatory cells.J. Clin. Invest., 115
-
M. Gavin, T. Torgerson, Evan Houston, P. Deroos, W. Ho, A. Stray-Pedersen, E. Ocheltree, P. Greenberg, H. Ochs, A. Rudensky (2006)
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.Proceedings of the National Academy of Sciences of the United States of America, 103 17
-
J. Fontenot, M. Gavin, A. Rudensky (2003)
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsNature Immunology, 4
-
O. Leavy (2007)
Autoimmunity: Regulatory T cells in autoimmunityNature Reviews Immunology, 7
-
(2006)
Molecular mechanisms underlying FOXP3 induction in human T cells -
S. Allan, L. Passerini, R. Bacchetta, N. Crellin, Minyue Dai, P. Orban, S. Ziegler, M. Roncarolo, M. Levings (2005)
The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.The Journal of clinical investigation, 115 11
-
M. Walker, Deborah Kasprowicz, V. Gersuk, Angèle Bénard, Megan Landeghen, J. Buckner, S. Ziegler (2003)
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells.The Journal of clinical investigation, 112 9
-
V. Trouet, Jan Esper, Nicholas Graham, Andy Baker, J. Scourse, David, C. Frank (2002)
Supporting Online Material -
J. Fontenot, A. Rudensky (2005)
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3Nature Immunology, 6
-
M. Morgan, J. Bilsen, A. Bakker, B. Heemskerk, M. Schilham, F. Hartgers, B. Elferink, L. Zanden, R. Vries, T. Huizinga, T. Ottenhoff, R. Toes (2005)
Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.Human immunology, 66 1
-
C. Hsieh, Ye Zheng, Yuqiong Liang, J. Fontenot, A. Rudensky (2006)
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoiresNature Immunology, 7
-
Gavin Gavin, Torgerson Torgerson, Houston Houston, deRoos deRoos, Ho Ho, Stray‐Pedersen Stray‐Pedersen, Ocheltree Ocheltree (2006)
Single‐cell analysis of normal and FOXP3‐mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci.USA, 103
-
J. Fontenot, M. Gavin, A. Rudensky (2003)
Foxp 3 programs the development and function of CD 4 + CD 25 + regulatory T cells -
J. Fontenot, J. Rasmussen, L. Williams, James Dooley, A. Farr, A. Rudensky (2005)
Regulatory T cell lineage specification by the forkhead transcription factor foxp3.Immunity, 22 3
-
S. Hickman, Jaeseok Yang, Rajan Thomas, A. Wells, L. Turka (2006)
Defective Activation of Protein Kinase C and Ras-ERK Pathways Limits IL-2 Production and Proliferation by CD4+CD25+ Regulatory T Cells1The Journal of Immunology, 177
-
S. Ziegler (2006)
FOXP3: of mice and men.Annual review of immunology, 24
-
S. Sakaguchi (2000)
Regulatory T cellsSpringer Seminars in Immunopathology, 28
-
Sakaguchi Sakaguchi (2000)
Regulatory T cells: key controllers of immunologic self‐tolerance.Cell, 101
-
C. Baecher-Allan, Julia Brown, G. Freeman, D. Hafler (2001)
CD4+CD25high Regulatory Cells in Human Peripheral Blood1The Journal of Immunology, 167
-
M. Levings, R. Sangregorio, M. Roncarolo (2001)
Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of FunctionThe Journal of Experimental Medicine, 193
-
E. Shevach (2000)
Regulatory T cells in autoimmmunity*.Annual review of immunology, 18
- Publisher
- Wiley
- Copyright
- Copyright © 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
- ISSN
- 0014-2980
- eISSN
- 1521-4141
- DOI
- 10.1002/eji.200636929
- pmid
- 17183612
- Publisher site
- See Article on Publisher Site
Abstract
The forkhead family transcription factor FOXP3 has been shown to be critical for the development and function of CD4+CD25+ regulatory T cells. Recently, FOXP3 expression has been shown to be induced upon activation of human CD4+ T cells. A new report in this issue of the European Journal of Immunology shows that expression of FOXP3 in activated T cell leads to hyporesponsiveness, but not necessarily to acquisition of suppressor function. This finding suggests a new role for FOXP3 in human CD4+ T cells: down‐modulating responses to TCR‐mediated stimulation. See accompanying article http://dx.doi.org/10.1002/eji.200636435
Journal
European Journal of Immunology – Wiley
Published: Jan 1, 2007