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- Publisher
- The American Physiological Society
- Copyright
- Copyright © 2012 the American Physiological Society
- ISSN
- 0022-3077
- eISSN
- 1522-1598
- DOI
- 10.1152/jn.00394.2012
- pmid
- 22745464
- Publisher site
- See Article on Publisher Site
Abstract
Neurons in the nucleus accumbens (NAc) have been shown to participate in several behavioral states, including feeding and sleep. However, it is not known if the same neuron participates in both states and, if so, how similar are the responses. In addition, since the NAc contains several cell types, it is not known if each type participates in the transitions associated with feeding and sleep. Such knowledge is important for understanding the interaction between two different neural networks. For these reasons we recorded ensembles of NAc neurons while individual rats volitionally transitioned between the following states: awake and goal directed, feeding, quiet-awake, and sleeping. We found that during both feeding and sleep states, the same neurons could increase their activity (be activated) or decrease their activity (be inactivated) by feeding and/or during sleep, thus indicating that the vast majority of NAc neurons integrate sleep and feeding signals arising from spatially distinct neural networks. In contrast, a smaller population was modulated by only one of the states. For the majority of neurons in either state, we found that when one population was excited, the other was inhibited, suggesting that they act as a local circuit. Classification of neurons into putative interneurons (fast-spiking interneurons (pFSI) and choline acetyltransferase interneurons (pChAT)) and projection medium spiny neurons (pMSN) showed that all three types are modulated by transitions to and from feeding and sleep states. These results show, for the first time, that in the NAc, those putative inhibitory interneurons respond similarly to pMSN projection neurons and demonstrate interactions between NAc networks involved in sleep and feeding. nucleus accumbens medium spiny neurons fast-spiking interneurons choline acetyltransferase freely licking Copyright © 2012 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print June 27, 2012 , doi: 10.1152/jn.00394.2012 AJP - JN Physiol September 15, 2012 vol. 108 no. 6 1739-1751 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: jn.00394.2012v1 108/6/1739 most recent Classifications Article Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Tellez, L. A. Articles by Gutierrez, R. PubMed PubMed citation Articles by Tellez, L. A. Articles by Gutierrez, R. Related Content Load related web page information Current Content September 15, 2012 Alert me to new issues of AJP - JN Physiol About the Journal Calls for Papers Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 0022-3077 Online ISSN: 1522-1598 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview(); } catch(err) {} var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-189672-30"); pageTracker._setDomainName(".physiology.org"); pageTracker._trackPageview(); } catch(err) {}
Journal
Journal of Neurophysiology – The American Physiological Society
Published: Sep 15, 2012