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- Publisher
- Karger
- Copyright
- © 2004 S. Karger AG, Basel
- ISSN
- 1015-9770
- eISSN
- 1421-9786
- DOI
- 10.1159/000075928
- Publisher site
- See Article on Publisher Site
Abstract
Background: Arterial remodeling exhibits a bidirectional capacity. Whether lumen size affects remodeling response to lesion change is unknown. Methods: Prospective study by duplex ultrasonography over 2 years in 61 subjects with coronary artery disease. Direction and magnitude of vessel remodeling are calculated for internal carotid, bifurcation, and common carotid artery segments. Results: A linear trend is discernible between lumen diameter and direction and magnitude of remodeling at sites of expanding intima-media thickness (IMT) or plaque. Rate of lesion change varied inversely with lesion thickness with an inflection between rates for low-dimension IMT and plaque. Conclusions: Dilatation versus shrinkage in the remodeling response to expanding lesions appears related to lumen size. IMT and plaque exhibit independent biologies.
Journal
Cerebrovascular Diseases – Karger
Published: Mar 1, 2004
Keywords: Plaque; Atherosclerosis; Blood flow; Ultrasonics; Human studies; Carotid arteries; Remodeling