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- Publisher
- Wiley
- Copyright
- Copyright © 2008 Wiley Subscription Services
- ISSN
- 1860-7179
- eISSN
- 1860-7187
- DOI
- 10.1002/cmdc.200800214
- pmid
- 18942693
- Publisher site
- See Article on Publisher Site
Abstract
Things don′t always add up: Our understanding of biomolecular recognition processes is often complicated by the fact that the binding contributions of individual ligand–protein subcontacts do not add up in a linear fashion. Chemical double‐mutant cycles are useful analyses to quantify the degree of nonadditivity in such binding phenomena, and peptidyl inhibitors of hepatitis C virus NS3 protease are used to exemplify this.
Journal
ChemMedChem – Wiley
Published: Jan 17, 2008
Keywords: ; ; ; ;