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References (25)
-
M. Tebano, A. Martire, N. Rebola, R. Pepponi, M. Domenici, Maria Grò, M. Schwarzschild, Jiang-Fan Chen, Rodrigo Cunha, P. Popoli (2005)
Adenosine A2A receptors and metabotropic glutamate 5 receptors are co‐localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N‐methyl‐d‐aspartate effectsJournal of Neurochemistry, 95
-
Younghwa Kim, Eun-Hae Kim, Soontaek Hong, I. Rhyu, Jeehyung Choe, Woong Sun, Hyun Kim (2006)
Expression of thymosin β in the rat brain following transient global ischemiaBrain Research, 1085
-
K. Morimoto, M. Fahnestock, R. Racine (2004)
Kindling and status epilepticus models of epilepsy: rewiring the brainProgress in Neurobiology, 73
-
T. Alexi, C. Borlongan, R. Faull, C. Williams, R. Clark, P. Gluckman, P. Hughes (2000)
Neuroprotective strategies for basal ganglia degeneration: Parkinson’s and Huntington’s diseasesProgress in Neurobiology, 60
-
P. Carpintero, R. Anadón, S. Díaz-Regueira, J. Gómez-Márquez (1999)
Expression of thymosin β4 messenger RNA in normal and kainate-treated rat forebrainNeuroscience, 90
-
N. Vartiainen, I. Pyykönen, T. Hökfelt, J. Koistinaho (1996)
Induction of thymosin beta(4) mRNA following focal brain ischemia.Neuroreport, 7 10
-
I. Bock-Marquette, A. Saxena, Michael White, J. DiMaio, D. Srivastava, D. Srivastava (2004)
Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repairNature, 432
-
T. Petit, J. Leboutillier, E. Markus, N. Milgram (1989)
Synaptic structural plasticity following repetitive activation in the rat hippocampusExperimental Neurology, 105
-
A. Goldstein, A. Guha, M. Zatz, M. Hardy, A. White (1972)
Purification and biological activity of thymosin, a hormone of the thymus gland.Proceedings of the National Academy of Sciences of the United States of America, 69 7
-
Edward Irobi, A. Aguda, M. Larsson, Christophe Guérin, H. Yin, L. Burtnick, L. Blanchoin, R. Robinson (2004)
Structural basis of actin sequestration by thymosin‐β4: implications for WH2 proteinsThe EMBO Journal, 23
-
N. Smart, Catherine Risebro, Athalie Melville, Kelvin Moses, R. Schwartz, K. Chien, P. Riley (2007)
Thymosin β4 induces adult epicardial progenitor mobilization and neovascularizationNature, 445
-
G. Sosne, Abdul-Rahman Albeiruti, B. Hollis, A. Siddiqi, D. Ellenberg, M. Kurpakus‐Wheater (2006)
Thymosin β4 inhibits benzalkonium chloride-mediated apoptosis in corneal and conjunctival epithelial cells in vitroExperimental Eye Research, 83
-
E. Sapp, K. Kegel, N. Aronin, T. Hashikawa, Y. Uchiyama, K. Tohyama, P. Bhide, J. Vonsattel, M. Difiglia (2001)
Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease BrainJNEN: Journal of Neuropathology & Experimental Neurology, 60
-
D. Philp, Allan Goldstein, H. Kleinman (2004)
Thymosin β4 promotes angiogenesis, wound healing, and hair follicle developmentMechanisms of Ageing and Development, 125
-
Y. Ben-Ari, A. Represa (1990)
Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampusTrends in Neurosciences, 13
-
N. Vartiainen, I. Pyykönen, T. Hökfelt, J. Koistinaho (1996)
Induction of Thymosin β4 mRNA Following Focal Brain IschemiaNeuroreport, 7
-
A. Dunah, R. Yasuda, Jianhong Luo, Yue‐hua Wang, K. Prybylowski, B. Wolfe (1999)
Biochemical studies of the structure and function of theN-methyl-D-aspartate subtype of glutamate receptorsMolecular Neurobiology, 19
-
M. Hynd, H. Scott, P. Dodd (2004)
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer’s diseaseNeurochemistry International, 45
-
P. Popoli, A. Pintor, M. Tebano, C. Frank, R. Pepponi, V. Nazzicone, R. Grieco, A. Pèzzola, R. Reggio, L. Minghetti, M. Berardinis, A. Martire, R. Potenza, M. Domenici, M. Massotti (2004)
Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid‐induced striatal toxicity: involvement of pre‐ and post‐synaptic mechanisms and lack of direct NMDA blocking activityJournal of Neurochemistry, 89
-
E. Kramár, B. Lin, Christopher Rex, C. Gall, G. Lynch (2006)
Integrin-driven actin polymerization consolidates long-term potentiation.Proceedings of the National Academy of Sciences of the United States of America, 103 14
-
J. Gómez-Márquez, M. Dosil, F. Segade, X. Bustelo, J. Pichel, F. Domı́nguez, M. Freire (1989)
Thymosin-beta 4 gene. Preliminary characterization and expression in tissues, thymic cells, and lymphocytes.Journal of immunology, 143 8
-
Younghwa Kim, Eun-Hae Kim, Soontaek Hong, I. Rhyu, Jeehyung Choe, Woong Sun, Hyun Kim (2006)
Expression of thymosin beta in the rat brain following transient global ischemia.Brain research, 1085 1
-
A. Goldstein, E. Hannappel, H. Kleinman (2005)
Thymosin β4: actin-sequestering protein moonlights to repair injured tissuesTrends in Molecular Medicine, 11
-
Jinghui Dong, Guoxin Ying, Xin Liu, Wenyuan Wang, Yan Wang, Z. Ni, Chang‐Fu Zhou (2005)
Expression of thymosin beta4 mRNA by activated microglia in the denervated hippocampusNeuroReport, 16
-
John Young, Anthony Lawrence, Andrew MacLean, B. Leung, Iain McInnes, Benito Cañas, Darryl Pappin, R. Stevenson (1999)
Thymosin β 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoidsNature Medicine, 5
- Publisher
- Wiley
- Copyright
- Copyright © 2007 Wiley Subscription Services
- ISSN
- 0077-8923
- eISSN
- 1749-6632
- DOI
- 10.1196/annals.1415.033
- pmid
- 17947590
- Publisher site
- See Article on Publisher Site
Abstract
Abstract: The aim of this study was to evaluate the possible neuroprotective effects of thymosin β4 in different models of excitotoxicity. The application of thymosin β4 significantly attenuated glutamate‐induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiments, the intracerebroventricular administration of thymosin β4 significantly reduced hippocampal neuronal loss induced by kainic acid. These results show that thymosin β4 induced a protective effect in models of excitotoxicity. The mechanisms underlying such an effect, as well as the real neuroprotective potential of thymosin β4, are worthy of further investigations.
Journal
Annals of the New York Academy of Sciences – Wiley
Published: Jan 1, 2007
Keywords: ;