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Oncogenic PI3K and its role in cancer

Oncogenic PI3K and its role in cancer Yardena Samuels and Kajsa Ericson Purpose of review Introduction The purpose of this review is to examine the contribution of Phosphoinositide kinases (PIKs) are lipid kinases that the PI3K signaling pathway to the development of human phosphorylate the inositol ring of phosphoinositides, thus tumors and to propose further studies to elucidate how to acting as signal transducers. Depending on the phos- develop therapeutics for patients with mutations in this phorylation site on the carbohydrate, PIKs are categorized pathway. into three families: phosphoinositide 3-kinases (PI3Ks), Recent findings phosphoinositide 4-kinases (PIP4Ks) and phosphoinosi- More than 30% of various solid tumor types were recently tide 5-kinases (PIP5Ks). PI3Ks are further grouped into found to contain mutations in PIK3CA, the catalytic subunit class I, II or III, depending on their subunit structure, their of PI3K. Further analysis of key genes in this pathway regulation and their substrate selectivity. Each class con- identified an additional eight genes altered in tumors. These tains various isoforms amounting to eight isoforms in total. were generally found to be mutated in a mutually exclusive manner, thus increasing the mutation frequency of the Class I PI3Ks exist as heterodimers composed of catalytic pathway to 40% in colorectal cancers and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Oncology Wolters Kluwer Health

Oncogenic PI3K and its role in cancer

Ericson, Kajsa
Current Opinion in Oncology , Volume 18 (1) – Jan 1, 2006
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ISSN
1040-8746
eISSN
1531-703X
DOI
10.1097/01.cco.0000198021.99347.b9
Publisher site
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Abstract

Yardena Samuels and Kajsa Ericson Purpose of review Introduction The purpose of this review is to examine the contribution of Phosphoinositide kinases (PIKs) are lipid kinases that the PI3K signaling pathway to the development of human phosphorylate the inositol ring of phosphoinositides, thus tumors and to propose further studies to elucidate how to acting as signal transducers. Depending on the phos- develop therapeutics for patients with mutations in this phorylation site on the carbohydrate, PIKs are categorized pathway. into three families: phosphoinositide 3-kinases (PI3Ks), Recent findings phosphoinositide 4-kinases (PIP4Ks) and phosphoinosi- More than 30% of various solid tumor types were recently tide 5-kinases (PIP5Ks). PI3Ks are further grouped into found to contain mutations in PIK3CA, the catalytic subunit class I, II or III, depending on their subunit structure, their of PI3K. Further analysis of key genes in this pathway regulation and their substrate selectivity. Each class con- identified an additional eight genes altered in tumors. These tains various isoforms amounting to eight isoforms in total. were generally found to be mutated in a mutually exclusive manner, thus increasing the mutation frequency of the Class I PI3Ks exist as heterodimers composed of catalytic pathway to 40% in colorectal cancers and

Journal

Current Opinion in Oncology – Wolters Kluwer Health

Published: Jan 1, 2006

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