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Inhibition of Ovulation Induced with PMS and HCG by a Melatonin-Free Extract of Bovine Pineal Powder

Inhibition of Ovulation Induced with PMS and HCG by a Melatonin-Free Extract of Bovine Pineal Powder Using borate buffer a substance that suppresses the ovulation induced with PMS and HCG in immature mice was obtained from acetone-defatted bovine pineal powder by an extraction method similar to that used for an extraction of a gonadotropin-inhibiting substance in urine. This gonadotropin inhibitor in the pineal powder differs from melatonin or arginine vasotocin and seems to be different from the water soluble antigonadotropic substance which has been isolated from the bovine and ovine pineal. Partial purification of the gonadotropin inhibitor was accomplished by a Sephadex G-100 column. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroendocrinology Karger

Inhibition of Ovulation Induced with PMS and HCG by a Melatonin-Free Extract of Bovine Pineal Powder

Ota, M.; Horiuchi, S.; Obara, K.
Neuroendocrinology , Volume 18 (4): 11 – Jan 1, 1975
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Publisher
Karger
Copyright
© 1975 S. Karger AG, Basel
ISSN
0028-3835
eISSN
1423-0194
DOI
10.1159/000122412
Publisher site
See Article on Publisher Site

Abstract

Using borate buffer a substance that suppresses the ovulation induced with PMS and HCG in immature mice was obtained from acetone-defatted bovine pineal powder by an extraction method similar to that used for an extraction of a gonadotropin-inhibiting substance in urine. This gonadotropin inhibitor in the pineal powder differs from melatonin or arginine vasotocin and seems to be different from the water soluble antigonadotropic substance which has been isolated from the bovine and ovine pineal. Partial purification of the gonadotropin inhibitor was accomplished by a Sephadex G-100 column.

Journal

Neuroendocrinology – Karger

Published: Jan 1, 1975

Keywords: Pineal; Antigonadotropin; Ovulation inhibitor

There are no references for this article.