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- Publisher
- Wiley
- Copyright
- Copyright © 1998 American Neurological Association
- ISSN
- 0364-5134
- eISSN
- 1531-8249
- DOI
- 10.1002/ana.410440521
- pmid
- 9818943
- Publisher site
- See Article on Publisher Site
Abstract
Human immunodeficiency virus–associated dementia (HAD) is associated with increased numbers of activated central nervous system (CNS) macrophages. Chemokines, which regulate infiltration of macrophages, were measured in the cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)‐negative and HIV‐positive individuals with and without neurological disese. Monocyte chemotactic protein (MCP)‐1 and RANTES (but not MCP‐3), macrophage inflammatory protein (MIP)‐1α, MIP‐1β, or interleukin‐8 (IL‐8) was higher in HAD. MCP‐1 correlated with CSF viral load and severity of dementia, and it increased over time in patients who developed dementia.
Journal
Annals of Neurology – Wiley
Published: Nov 1, 1998