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References (45)
-
L. Meijer, D. Arion, R. Golsteyn, J. Pines, L. Brizuela, T. Hunt, D. Beach (1989)
Cyclin is a component of the sea urchin egg M‐phase specific histone H1 kinase.The EMBO Journal, 8
-
G. Draetta, F. Luca, J. Westendorf, L. Brizuela, J. Ruderman, D. Beach (1989)
cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPFCell, 56
-
J. Piggott, R. Rai, Bruce Carter (1982)
A bifunctional gene product involved in two phases of the yeast cell cycleNature, 298
-
P. Nurse, Y. Bissett (1981)
Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeastNature, 292
-
L. Cisek, J. Corden (1989)
Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2Nature, 339
-
R. Grandori, M. Vai, M. Renzo, L. Alberghina, L. Popolo (1989)
Identification of a protein cross-reacting with anti-phosphotyrosine antibodies in yeast insoluble cytoplasmic matrices.Biochemical and biophysical research communications, 160 2
-
M. Kamps, B. Sefton (1988)
Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.Oncogene, 2 4
-
J. Labbé, A. Picard, G. Peaucellier, J. Cavadore, P. Nurse, M. Dorée (1989)
Purification of MPF from starfish: Identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activationCell, 57
-
Melanie Lee, P. Nurse (1987)
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2Nature, 327
-
J. Hindley, G. Phear (1984)
Sequence of the cell division gene CDC2 from Schizosaccharomyces pombe; patterns of splicing and homology to protein kinases.Gene, 31 1-3
-
Steven Reed, J. Hadwiger, Attila Lorincz (1985)
Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28.Proceedings of the National Academy of Sciences of the United States of America, 82 12
-
V. Simanis, P. Nurse (1986)
The cell cycle control gene cdc2 + of fission yeast encodes a protein kinase potentially regulated by phosphorylationCell, 45
-
R. Booher, D. Beach (1986)
Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombeMolecular and Cellular Biology, 6
-
B. Edgar, P. O’Farrell (1989)
Genetic control of cell division patterns in the Drosophila embryoCell, 57
-
G. Draetta, H. Piwnica-Worms, D. Morrison, B. Druker, Thomas Roberts, D. Beach (1988)
Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrateNature, 336
-
R. Booher, C. Alfa, J. Hyams, D. Beach (1989)
The fission yeast cdc2/cdc13/suc1 protein kinase: Regulation of catalytic activity and nuclear localizationCell, 58
-
S. Reed (1980)
The selection of S. cerevisiae mutants defective in the start event of cell division.Genetics, 95 3
-
J. Gautier, C. Norbury, M. Lohka, P. Nurse, J. Maller (1988)
Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2 +Cell, 54
-
P. Russell, P. Nurse (1987)
Negative regulation of mitosis by wee1 +, a gene encoding a protein kinase homologCell, 49
-
W. Dunphy, J. Newport (1989)
Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinaseCell, 58
-
S. Hanks, A. Quinn, T. Hunter (1988)
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.Science, 241 4861
-
J. Pines, T. Hunter (1989)
Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2Cell, 58
-
M. Solomon, R. Booher, M. Kirschner, D. Beach (1988)
Cyclin in fission yeastCell, 54
-
Iain Hagan, J. Hayles, Paul Nurse (1988)
Cloning and sequencing of the cyclin-related cdc13+ gene and a cytological study of its role in fission yeast mitosis.Journal of cell science, 91 ( Pt 4)
-
A. Frackelton, A. Ross, H. Eisen (1983)
Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cellsMolecular and Cellular Biology, 3
-
A. Morla, G. Draetta, D. Beach, Jean Wang (1989)
Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosisCell, 58
-
J. Gautier, T. Matsukawa, P. Nurse, J. Maller (1989)
Dephosphorylation and activation of Xenopusp34cdc2 protein kinase during the cell cycleNature, 339
-
P. Russell, P. Nurse (1986)
cdc25 + functions as an inducer in the mitotic control of fission yeastCell, 45
-
Wilhelm Krek, Erich Nigg (1989)
Structure and developmental expression of the chicken CDC2 kinase.The EMBO Journal, 8
-
J. Cooper, B. Sefton, T. Hunter (1983)
Detection and quantification of phosphotyrosine in proteins.Methods in enzymology, 99
-
T. Hunter, B. Sefton (1980)
Transforming gene product of Rous sarcoma virus phosphorylates tyrosineProceedings of the National Academy of Sciences, 77
-
R. Booher, David Beach (1988)
Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules.The EMBO Journal, 7
-
J. Hadwiger, S. Reed (1988)
Invariant phosphorylation of the Saccharomyces cerevisiae Cdc28 protein kinaseMolecular and Cellular Biology, 8
-
P. Fantes (1981)
Isolation of cell size mutants of a fission yeast by a new selective method: characterization of mutants and implications for division control mechanismsJournal of Bacteriology, 146
-
P. Nurse, P. Thuriaux (1980)
Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe.Genetics, 96 3
-
G. Draetta, D. Beach (1988)
Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangementCell, 54
-
G. Schieven, J. Thorner, G. Martin (1986)
Protein-tyrosine kinase activity in Saccharomyces cerevisiae.Science, 231 4736
-
B. Shapiro, E. Stadtman (1968)
5'-adenylyl-O-tyrosine. The novel phosphodiester residue of adenylylated glutamine synthetase from Escherichia coli.The Journal of biological chemistry, 243 13
-
R. Castellanos, M. Mazón (1985)
Identification of phosphotyrosine in yeast proteins and of a protein tyrosine kinase associated with the plasma membrane.The Journal of biological chemistry, 260 14
-
S. Moreno, J. Hayles, P. Nurse (1989)
Regulation of p34cdc2 protein kinase during mitosisCell, 58
-
W. Dunphy, L. Brizuela, D. Beach, J. Newport (1988)
The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosisCell, 54
-
Leah Lipsich, Joans Brugge (1983)
Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma virusesJournal of Virology, 48
-
G. Draetta, L. Brizuela, J. Potashkin, D. Beach (1987)
Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2 + and suc1 +Cell, 50
-
P. Russell, S. Moreno, S. Reed (1989)
Conservation of mitotic controls in fission and budding yeastsCell, 57
-
K. Gould, T. Hunter (1988)
Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activityMolecular and Cellular Biology, 8
- Publisher
- Springer Journals
- Copyright
- Copyright © 1989 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/342039a0
- Publisher site
- See Article on Publisher Site
Abstract
The cdc2 + protein kinase (pp34) is found to be phosphorylated on tyrosine as well as serine and threonine residues in exponentially growing Schizosaccharomyces pombe. At mitosis, the level of pp34 phosphorylation on both threonine and tyrosine residues decreases. The single detectable site of tyrosine phosphorylation in pp34 has been mapped to Tyr 15, a residue within the presumptive ATP-binding domain. Substitution of this tyrosine by phenylalanine advances cells prematurely into mitosis, establishing that tyrosine phosphorylation/dephosphorylation directly regulates pp34 function.
Journal
Nature – Springer Journals
Published: Nov 2, 1989