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Obesity: a challenge for science and society

Obesity: a challenge for science and society EDITORIAL www.nature.com/clinicalpractice/cardio Valentin Fuster In 1995, 200 million adults were obese (BMI other has been challenging but is enabling new In the US, 4.2% >30 kg/m ), and that number had reached treatments to be developed. The adipocyte, of people aged 300 million by 2004. Obesity and overweight or fat cell of the abdominal adipose tissue, is 12–19 years prevalence is rising in young people worldwide. thought to be a source of tumor necrosis fac- are thought to Today, one in every ten children is overweight, tor and of other high cytokine concentrations totaling 155 million, 30–45 million of whom are (inter leukins 6 and 18 and P-selectin). Tumor be affected by classified as obese. This problem affects not necrosis factor might cause impairment in the metabolic only industrialized nations but also low-income insulin signaling leading to insulin resistance syndrome, and middle-income countries. and hyperglycemia, both of which contribute and that The risk of heart disease and stroke to endothelial damage and atherogenesis. The increases with increasing BMI. Additional percentage other cytokine excesses may lead, directly associations have been made with abdo minal or mediated by the liver, to an inflammatory is rising obesity, insulin resistance and diabetes, raised http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Reviews Cardiology Springer Journals

Obesity: a challenge for science and society

Fuster, Valentin
Nature Reviews Cardiology , Volume 2 (1) – Jan 1, 2005
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Obesity: a challenge for science and society

Abstract

EDITORIAL www.nature.com/clinicalpractice/cardio Valentin Fuster In 1995, 200 million adults were obese (BMI other has been challenging but is enabling new In the US, 4.2% >30 kg/m ), and that number had reached treatments to be developed. The adipocyte, of people aged 300 million by 2004. Obesity and overweight or fat cell of the abdominal adipose tissue, is 12–19 years prevalence is rising in young people worldwide. thought to be a source of tumor necrosis fac- are thought to...
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Publisher
Springer Journals
Copyright
Copyright © 2005 by Nature Publishing Group
Subject
Medicine & Public Health; Medicine/Public Health, general; Cardiology; Cardiac Imaging; Cardiac Surgery
ISSN
1759-5002
eISSN
1743-4300
DOI
10.1038/ncpcardio0070
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL www.nature.com/clinicalpractice/cardio Valentin Fuster In 1995, 200 million adults were obese (BMI other has been challenging but is enabling new In the US, 4.2% >30 kg/m ), and that number had reached treatments to be developed. The adipocyte, of people aged 300 million by 2004. Obesity and overweight or fat cell of the abdominal adipose tissue, is 12–19 years prevalence is rising in young people worldwide. thought to be a source of tumor necrosis fac- are thought to Today, one in every ten children is overweight, tor and of other high cytokine concentrations totaling 155 million, 30–45 million of whom are (inter leukins 6 and 18 and P-selectin). Tumor be affected by classified as obese. This problem affects not necrosis factor might cause impairment in the metabolic only industrialized nations but also low-income insulin signaling leading to insulin resistance syndrome, and middle-income countries. and hyperglycemia, both of which contribute and that The risk of heart disease and stroke to endothelial damage and atherogenesis. The increases with increasing BMI. Additional percentage other cytokine excesses may lead, directly associations have been made with abdo minal or mediated by the liver, to an inflammatory is rising obesity, insulin resistance and diabetes, raised

Journal

Nature Reviews Cardiology – Springer Journals

Published: Jan 1, 2005

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