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/lp/karger/exocrine-pancreatic-function-in-insulin-dependent-diabetes-mellitus-sGY7ymrfYx
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- Publisher
- Karger
- Copyright
- © 1982 S. Karger AG, Basel
- ISSN
- 0012-2823
- eISSN
- 1421-9867
- DOI
- 10.1159/000198833
- Publisher site
- See Article on Publisher Site
Abstract
Exocrine pancreatic function was studied in patients with long-standing insulin-dependent diabetes mellitus using the secretin-pancreozymin test (n = 53), and estimation of immunoreactive trypsin (n = 43) and pancreatic isoamylase (n = 43). The secretin-pancreozymin test was abnormal in 23 patients (43 %). The abnormalities found were a decreased output of lipase (37%), amylase (36%) or trypsin (26%) and bicarbonate (15%). Serum immunoreactive trypsin was below normal in only 6 (14%) and pancreatic isoamylase in 29 (67%) patients. There was no correlation between impairment of the secretin-pancreozymin test and decreased serum enzyme levels. It is concluded that an impairment of exocrine pancreatic function is frequent in insulin-dependent diabetics but that a decrease in serum enzymes, especially in pancreatic isoamylase, does not reflect an impairment of pancreatic function in these patients.
Journal
Digestion – Karger
Published: Jan 1, 1982
Keywords: Pancreatic isoamylase; Hb A1a+b+c; Insulin-dependent diabetes mellitus; Exocrine pancreatic function; Secretin-pancreozymin test; Serum trypsin (RIA)