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Neuropeptide Y functions as a neuroproliferative factor

Neuropeptide Y functions as a neuroproliferative factor Neuropeptide Y (NPY) has a number of functions in mammalian physiology 1,2,3,4,5,6 . Here we identify a role for NPY in promoting proliferation of postnatal neuronal precursor cells. NPY is synthesized in the postnatal olfactory epithelium by sustentacular cells, previously proposed to function only in structural support 7 . Mice with a targeted deletion of NPY 8 contain half as many dividing olfactory neuronal precursor cells as do controls. Furthermore, NPY-deficient mice develop significantly fewer olfactory neurons by adulthood. NPY acts on multipotent neuronal precursor or basal cells to activate rapidly and transiently the extracellular signal-regulated kinase (ERK)1/2 subgroup of mitogen-activated protein kinases. The NPY Y1 receptor subtype appears to mediate this effect. The ability of NPY to induce neuronal precursor proliferation is mediated by protein kinase C (PKC), indicating an upstream PKC-dependent activation of ERK1/2. These results indicate that NPY may regulate neuronal precursor proliferation in the adult mammal. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Neuropeptide Y functions as a neuroproliferative factor

Hansel, D. E.; Eipper, B. A.; Ronnett, G. V.
Nature , Volume 410 (6831) – Apr 19, 2001
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References (33)

Publisher
Springer Journals
Copyright
Copyright © 2001 by Macmillan Magazines Ltd.
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/35073601
Publisher site
See Article on Publisher Site

Abstract

Neuropeptide Y (NPY) has a number of functions in mammalian physiology 1,2,3,4,5,6 . Here we identify a role for NPY in promoting proliferation of postnatal neuronal precursor cells. NPY is synthesized in the postnatal olfactory epithelium by sustentacular cells, previously proposed to function only in structural support 7 . Mice with a targeted deletion of NPY 8 contain half as many dividing olfactory neuronal precursor cells as do controls. Furthermore, NPY-deficient mice develop significantly fewer olfactory neurons by adulthood. NPY acts on multipotent neuronal precursor or basal cells to activate rapidly and transiently the extracellular signal-regulated kinase (ERK)1/2 subgroup of mitogen-activated protein kinases. The NPY Y1 receptor subtype appears to mediate this effect. The ability of NPY to induce neuronal precursor proliferation is mediated by protein kinase C (PKC), indicating an upstream PKC-dependent activation of ERK1/2. These results indicate that NPY may regulate neuronal precursor proliferation in the adult mammal.

Journal

Nature – Springer Journals

Published: Apr 19, 2001

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