Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Effect of sub‐inhibitory concentrations of antibiotics on the virulence of Staphylococcus aureus

Effect of sub‐inhibitory concentrations of antibiotics on the virulence of Staphylococcus aureus The production of virulence factors by various bacteria can be influenced by sub‐inhibitory concentrations of antibiotics. The effect of six antibiotics on the production of representative extracellular enzymes and toxins produced by Staphylococcus aureus was investigated. The production of the virulence determinants coagulase, protein A, alpha and delta haemolysin was monitored in the presence of ciprofloxacin, enoxacin, chloramphenicol, gentamicin, tetracycline and methicillin. The protein synthesis inhibitors reduced the production of coagulase and protein A, and almost completely inhibited the production of the haemolysins. Haemolysin production was also reduced by ciprofloxacin and enoxacin, but these antibiotics had little effect on the production of coagulase and protein A. Methicillin stimulated the production of alpha and delta haemolysins but had no effect on the production of coagulase and protein A. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Microbiology Oxford University Press

Effect of sub‐inhibitory concentrations of antibiotics on the virulence of Staphylococcus aureus

Download PDF
6 pages

Loading next page...
 
/lp/oxford-university-press/effect-of-sub-inhibitory-concentrations-of-antibiotics-on-the-sUYKqwN80N

References (23)

Publisher
Oxford University Press
Copyright
"Copyright © 1993 Wiley Subscription Services, Inc., A Wiley Company"
ISSN
1364-5072
eISSN
1365-2672
DOI
10.1111/j.1365-2672.1993.tb02756.x
Publisher site
See Article on Publisher Site

Abstract

The production of virulence factors by various bacteria can be influenced by sub‐inhibitory concentrations of antibiotics. The effect of six antibiotics on the production of representative extracellular enzymes and toxins produced by Staphylococcus aureus was investigated. The production of the virulence determinants coagulase, protein A, alpha and delta haemolysin was monitored in the presence of ciprofloxacin, enoxacin, chloramphenicol, gentamicin, tetracycline and methicillin. The protein synthesis inhibitors reduced the production of coagulase and protein A, and almost completely inhibited the production of the haemolysins. Haemolysin production was also reduced by ciprofloxacin and enoxacin, but these antibiotics had little effect on the production of coagulase and protein A. Methicillin stimulated the production of alpha and delta haemolysins but had no effect on the production of coagulase and protein A.

Journal

Journal of Applied Microbiology – Oxford University Press

Published: Aug 1, 1993

There are no references for this article.