Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Heterogenous properties of dentate granule neurons in the adult rat

Heterogenous properties of dentate granule neurons in the adult rat Postnatal neurogenesis contributes substantially to the neuronal population of the adult dentate gyrus. We report here that the neurons located in the deep aspects of the granule cell layer, near the proliferative zone, have different properties from those located in the superficial layers. The former group of neurons, tentatively designated as young, can be readily identified in a standard hippocampal slice preparation by morphological, immunohistochemical, and electrophysiological criteria. Electrophysiological recordings and imaging with Lucifer yellow from these neurons in the standard hippocampal slice preparation showed one or two main dendrites and conically shaped branches possessing varicose protrusions. These features are in agreement with the appearance of the same population of young neurons immunopositive for TOAD‐64, a marker for immature neurons. In disinhibited slices, these putative young neurons are distinguished from the mature neurons, located in the superficial granule cell layer, by showing paired pulse facilitation and having a lower threshold for induction of long‐term potentiation. The putative young neurons are completely unaffected by GABAA inhibition and always display robust long‐term potentiation. In contrast, the mature neurons never produce long‐term potentiation when the GABAA inhibition is intact. We propose that the heterogeneity of the functional properties of the granule neurons is related to the ongoing neurogenesis in the adult animals. © 2000 John Wiley & Sons, Inc. J Neurobiol 42: 248–257, 2000 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Developmental Neurobiology Wiley

Heterogenous properties of dentate granule neurons in the adult rat

Download PDF
10 pages

Loading next page...
 
/lp/wiley/heterogenous-properties-of-dentate-granule-neurons-in-the-adult-rat-scsRcGOe1d

References (42)

Publisher
Wiley
Copyright
Copyright © 2000 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1932-8451
eISSN
1932-846X
DOI
10.1002/(SICI)1097-4695(20000205)42:2<248::AID-NEU8>3.0.CO;2-J
Publisher site
See Article on Publisher Site

Abstract

Postnatal neurogenesis contributes substantially to the neuronal population of the adult dentate gyrus. We report here that the neurons located in the deep aspects of the granule cell layer, near the proliferative zone, have different properties from those located in the superficial layers. The former group of neurons, tentatively designated as young, can be readily identified in a standard hippocampal slice preparation by morphological, immunohistochemical, and electrophysiological criteria. Electrophysiological recordings and imaging with Lucifer yellow from these neurons in the standard hippocampal slice preparation showed one or two main dendrites and conically shaped branches possessing varicose protrusions. These features are in agreement with the appearance of the same population of young neurons immunopositive for TOAD‐64, a marker for immature neurons. In disinhibited slices, these putative young neurons are distinguished from the mature neurons, located in the superficial granule cell layer, by showing paired pulse facilitation and having a lower threshold for induction of long‐term potentiation. The putative young neurons are completely unaffected by GABAA inhibition and always display robust long‐term potentiation. In contrast, the mature neurons never produce long‐term potentiation when the GABAA inhibition is intact. We propose that the heterogeneity of the functional properties of the granule neurons is related to the ongoing neurogenesis in the adult animals. © 2000 John Wiley & Sons, Inc. J Neurobiol 42: 248–257, 2000

Journal

Developmental Neurobiology – Wiley

Published: May 5, 2000

Keywords: ; ; ; ;

There are no references for this article.