Establishment of Histological Criteria for High-risk Node-negative Breast Carcinoma for a Multi-institutional Randomized Clinical Trial of Adjuvant Therapy

Hitoshi Tsuda, Futoshi Akiyama, Masafumi Kurosumi, Goi Sakamoto, Toru Watanabe

doi:10.1093/jjco/28.8.486

Hitoshi Tsuda, Futoshi Akiyama, Masafumi Kurosumi, Goi Sakamoto, Toru Watanabe

1998-08-01 00:00:00

Background: A multi-institutional randomized clinical trial of adjuvant therapy for patients with high-risk node-negative (n0) breast cancer has been undertaken in Japan. The pathology panel was organized in order to establish histological criteria to identify patient groups with higher rates of recurrence. Methods: Initially, three pathologists independently judged the nuclear grade, composed of nuclear atypia and mitotic counts, of 100 n0 invasive ductal carcinomas, focusing on interobserver variation of the nuclear grade and its correlation with patient prognosis. These pathologists then gave consensus histological types and nuclear grades for 130 other n0 breast carcinomas and examined the prognostic significance of the grade. Results: In the first study, nuclear grade 2–3 significantly identified a patient group with a rate of recurrence of 17–20% by any pathologists and the degree of agreement for the grade was fair. In the second study, the consensus type and nuclear grade identifed a group ( n = 66) with a 22% recurrence rate and another group (n = 64) with a 3.6% recurrence rate at 10 years. In 12 tumors, the resection-fixation interval of the tumor did not generate any significant difference in mitotic counts. Conclusions: The histological type and the nuclear grade clearly identified a higher-risk patient group with n0 breast carcinoma, and may be applied to the multi-institutional protocol study when the criteria have been well standardized by the pathologists. Key words Key words node-negative breast cancer nuclear atypia mitotic counts prognostic factor interobserver variations Abbreviations NSAS-BC National Surgical Adjuvant Study of Breast Cancer CMF cyclophosphamide, methotrexate and 5-fluorouracil HE hematoxylin-eosin DCIS ductal carcinoma in situ IDC invasive ductal carcinoma ILC invasive lobular carcinoma SE standard error © 1998 Foundation for Promotion of Cancer Research « Previous | Next Article » Table of Contents This Article Jpn. J. Clin. Oncol. 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Japanese Journal of Clinical Oncology Oxford University Press

http://www.deepdyve.com/lp/oxford-university-press/establishment-of-histological-criteria-for-high-risk-node-negative-sfHobyRuZx

Establishment of Histological Criteria for High-risk Node-negative Breast Carcinoma for a Multi-institutional Randomized Clinical Trial of Adjuvant Therapy

$Background: A multi-institutional randomized clinical trial of adjuvant therapy for patients with high-risk node-negative (n0) breast cancer has been undertaken in Japan. The pathology panel was organized in order to establish histological criteria to identify patient groups with higher rates of recurrence. Methods: Initially, three pathologists independently judged the nuclear grade, composed of nuclear atypia and mitotic counts, of 100 n0 invasive ductal carcinomas, focusing on interobserver variation of the nuclear grade and its correlation with patient prognosis. These pathologists then gave consensus histological types and nuclear grades for 130 other n0 breast carcinomas and examined the prognostic significance of the grade. Results: In the first study, nuclear grade 2–3 significantly identified a patient group with a rate of recurrence of 17–20% by any pathologists and the degree of agreement for the grade was fair. In the second study, the consensus type and nuclear grade identifed a group ( n = 66) with a 22% recurrence rate and another group (n = 64) with a 3.6% recurrence rate at 10 years. In 12 tumors, the resection-fixation interval of the tumor did not generate any significant difference in mitotic counts. Conclusions: The histological type and the nuclear grade clearly identified a higher-risk patient group with n0 breast carcinoma, and may be applied to the multi-institutional protocol study when the criteria have been well standardized by the pathologists. Key words Key words node-negative breast cancer nuclear atypia mitotic counts prognostic factor interobserver variations Abbreviations NSAS-BC National Surgical Adjuvant Study of Breast Cancer CMF cyclophosphamide, methotrexate and 5-fluorouracil HE hematoxylin-eosin DCIS ductal carcinoma in situ IDC invasive ductal carcinoma ILC invasive lobular carcinoma SE standard error © 1998 Foundation for Promotion of Cancer Research « Previous | Next Article » Table of Contents This Article Jpn. J. Clin. Oncol. (1998) 28 (8): 486-491. doi: 10.1093/jjco/28.8.486 » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Original Articles Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Tsuda, H. Articles by Watanabe, T. Search for related content PubMed PubMed citation Articles by Tsuda, H. Articles by Akiyama, F. Articles by Kurosumi, M. Articles by Sakamoto, G. Articles by Watanabe, T. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? Search this journal: Advanced » Current Issue November 2015 45 (11) Alert me to new issues The Journal About this journal JJCO Editorial Office Rights & Permissions Dispatch date of the next issue This journal is a member of the Committee on Publication Ethics (COPE) We are mobile – find out more Journals Career Network Impact factor: 2.016 5-Yr impact factor: 2.036 Editor-in-Chief Tadao Kakizoe View full editorial board View/Download Reviewer Board List Thank you: Reviewers of 2014 For Authors Instructions to authors Online submission Online submission instruction Open Access options for authors - visit Oxford Open This journal enables compliance with the NIH Public Access Policy Self-archiving policy Alerting Services Email table of contents Email Advance Access CiteTrack XML RSS feed Corporate Services Advertising sales Reprints Supplements var taxonomies = ("MED00300"); Most Most Read Is Peritoneal Carcinomatosis an Incurable Disease or Controllable Locoregional Condition? -- Challenge of Surgeons with Intraperitoneal Hyperthermic Chemotherapy Cancer and the Philippine Cancer Control Program Significance of Free to Total PSA Ratio in Men with Slightly Elevated Serum PSA Levels: A Cooperative Study Overview of Cancer in Malaysia Multiple Liver Metastases of Breast Cancer: Report of a Case Successfully Treated with Hormone--Cytokine--Chemotherapy » View all Most Read articles Most Cited Toxicity Grading Criteria of the Japan Clinical Oncology Group Screening for Psychological Distress in Japanese Cancer Patients Phase II Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Sorafenib in Japanese Patients with Advanced Renal Cell Carcinoma Cancer Incidence and Incidence Rates in Japan in 2002: Based on Data from 11 Population-based Cancer Registries Evaluation Based on Systematic Review of Epidemiological Evidence Among Japanese Populations: Tobacco Smoking and Total Cancer Risk » View all Most Cited articles Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department. 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Establishment of Histological Criteria for High-risk Node-negative Breast Carcinoma for a Multi-institutional Randomized Clinical Trial of Adjuvant Therapy

Establishment of Histological Criteria for High-risk Node-negative Breast Carcinoma for a Multi-institutional Randomized Clinical Trial of Adjuvant Therapy

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Establishment of Histological Criteria for High-risk Node-negative Breast Carcinoma for a Multi-institutional Randomized Clinical Trial of Adjuvant Therapy

Establishment of Histological Criteria for High-risk Node-negative Breast Carcinoma for a Multi-institutional Randomized Clinical Trial of Adjuvant Therapy

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