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Artificial models of the natural SNARE proteins containing the native linker regions (light blue/gray) and the transmembrane domains (TMDs) of synatobrevin (Syb, violet) and syntaxis‐1A (Sx, orange) along with a peptide nucleic acid (PNA) recognition motif can align with either an antiparallel (see picture) or parallel orientation of the interacting strands. These hybrids induce the hemifusion and partial bilayer fusion of phospholipid vesicles.
Angewandte Chemie International Edition – Wiley
Published: Sep 5, 2011
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