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Long chain n-3 polyunsaturated fatty acids reduce atrial vulnerability in a novel canine pacing model

Long chain n-3 polyunsaturated fatty acids reduce atrial vulnerability in a novel canine pacing... AimOur objective was to assess the effect of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on atrial fibrillation (AF) vulnerability and atrial structure in a new model of atrial cardiomyopathy.Methods and resultsDogs were studied in three groups: seven control dogs (UNPACED) and 24 dogs undergoing simultaneous atrioventricular pacing (for 2 weeks) assigned to placebo treatment (SAVP-PLACEBO, n 12 dogs) or oral n-3 PUFAs (1 g/day) treatment (SAVP-PUFA, n 12 dogs). SAVP-PUFA dogs had less AF inducibility (percentage of burst attempts leading to AF episodes: 5.5 7.4 vs. 20.4 14.2, P < 0.001) and maintenance [median AF duration: 601 s (3771216) vs. 1598 s (11952400), P < 0.05] than SAVP-PLACEBO dogs. SAVP-PUFA dogs had significantly less local slowing of conduction and conduction heterogeneity than SAVP-PLACEBO dogs. SAVP-PUFA dogs had a significantly smaller increase in atrial matrix metalloproteinase-9 activity and in collagen type I and III messenger RNA expression (in arbitrary units) than SAVP-PLACEBO dogs (0.62 0.51 vs. 10.80 5.61, respectively for collagen I, P < 0.05; 1.66 0.48 vs. 5.24 1.16, respectively, for collagen III, P < 0.05).Conclusionn-3 PUFA supplementation can reduce AF vulnerability in a new canine pacing model of atrial cardiomyopathy. The mechanism may be related to attenuation of collagen turnover. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cardiovascular Research Oxford University Press

Long chain n-3 polyunsaturated fatty acids reduce atrial vulnerability in a novel canine pacing model

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References (45)

Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
Subject
ORIGINAL ARTICLES
ISSN
0008-6363
eISSN
1755-3245
DOI
10.1093/cvr/cvm024
pmid
18006468
Publisher site
See Article on Publisher Site

Abstract

AimOur objective was to assess the effect of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on atrial fibrillation (AF) vulnerability and atrial structure in a new model of atrial cardiomyopathy.Methods and resultsDogs were studied in three groups: seven control dogs (UNPACED) and 24 dogs undergoing simultaneous atrioventricular pacing (for 2 weeks) assigned to placebo treatment (SAVP-PLACEBO, n 12 dogs) or oral n-3 PUFAs (1 g/day) treatment (SAVP-PUFA, n 12 dogs). SAVP-PUFA dogs had less AF inducibility (percentage of burst attempts leading to AF episodes: 5.5 7.4 vs. 20.4 14.2, P < 0.001) and maintenance [median AF duration: 601 s (3771216) vs. 1598 s (11952400), P < 0.05] than SAVP-PLACEBO dogs. SAVP-PUFA dogs had significantly less local slowing of conduction and conduction heterogeneity than SAVP-PLACEBO dogs. SAVP-PUFA dogs had a significantly smaller increase in atrial matrix metalloproteinase-9 activity and in collagen type I and III messenger RNA expression (in arbitrary units) than SAVP-PLACEBO dogs (0.62 0.51 vs. 10.80 5.61, respectively for collagen I, P < 0.05; 1.66 0.48 vs. 5.24 1.16, respectively, for collagen III, P < 0.05).Conclusionn-3 PUFA supplementation can reduce AF vulnerability in a new canine pacing model of atrial cardiomyopathy. The mechanism may be related to attenuation of collagen turnover.

Journal

Cardiovascular Research – Oxford University Press

Published: Jan 1, 2008

Keywords: Keywords Polyunsaturated fatty acids atrial fibrillation canine pacing model collagen

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