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MDM2 and CDK4 Immunohistochemical Coexpression in High-grade Osteosarcoma Correlation With a Dedifferentiated Subtype

MDM2 and CDK4 Immunohistochemical Coexpression in High-grade Osteosarcoma Correlation With a... ORIGINAL ARTICLE MDM2 and CDK4 Immunohistochemical Coexpression in High-grade Osteosarcoma: Correlation With a Dedifferentiated Subtype Akihiko Yoshida, MD,*w Tetsuo Ushiku, MD, PhD,w Toru Motoi, MD, PhD,z Yasuo Beppu, MD,y Masashi Fukayama, MD, PhD,w Hitoshi Tsuda, MD, PhD,* and Tatsuhiro Shibata, MD, PhD*8 osteosarcomas, and immunohistochemistry may help identify this Abstract: Low-grade osteosarcomas comprise a distinct subset dedifferentiated subgroup to facilitate accurate subclassification. of osteosarcomas. They may occasionally dedifferentiate into Key Words: CDK4, dedifferentiation, immunohistochemistry, high-grade tumors, typically in the form of high-grade osteo- MDM2, osteosarcoma sarcoma, which are histologically indistinguishable from con- ventional osteosarcomas. MDM2 and CDK4 are often amplified (Am J Surg Pathol 2012;36:423–431) in low-grade osteosarcomas and their dedifferentiated counter- parts, and the encoded proteins are accordingly overexpressed. As MDM2/CDK4 expression was reportedly rare in conven- tional osteosarcoma, we hypothesized that these markers may ow-grade osteosarcomas, that is parosteal osteo- help separate dedifferentiated osteosarcoma from the conven- Lsarcoma and low-grade central osteosarcoma, com- tional type. To test this, we performed MDM2 and CDK4 im- prise a distinct subset accounting for 5% of all munohistochemistry on 81 primary and 26 recurrent/metastatic osteosarcomas. Parosteal osteosarcomas typically arise high-grade osteosarcomas and correlated these data with the on the surface of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Surgical Pathology Wolters Kluwer Health

MDM2 and CDK4 Immunohistochemical Coexpression in High-grade Osteosarcoma Correlation With a Dedifferentiated Subtype

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Copyright
Copyright © 2012 by Lippincott Williams & Wilkins
ISSN
0147-5185
eISSN
1532-0979
DOI
10.1097/PAS.0b013e31824230d0
pmid
22301501
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE MDM2 and CDK4 Immunohistochemical Coexpression in High-grade Osteosarcoma: Correlation With a Dedifferentiated Subtype Akihiko Yoshida, MD,*w Tetsuo Ushiku, MD, PhD,w Toru Motoi, MD, PhD,z Yasuo Beppu, MD,y Masashi Fukayama, MD, PhD,w Hitoshi Tsuda, MD, PhD,* and Tatsuhiro Shibata, MD, PhD*8 osteosarcomas, and immunohistochemistry may help identify this Abstract: Low-grade osteosarcomas comprise a distinct subset dedifferentiated subgroup to facilitate accurate subclassification. of osteosarcomas. They may occasionally dedifferentiate into Key Words: CDK4, dedifferentiation, immunohistochemistry, high-grade tumors, typically in the form of high-grade osteo- MDM2, osteosarcoma sarcoma, which are histologically indistinguishable from con- ventional osteosarcomas. MDM2 and CDK4 are often amplified (Am J Surg Pathol 2012;36:423–431) in low-grade osteosarcomas and their dedifferentiated counter- parts, and the encoded proteins are accordingly overexpressed. As MDM2/CDK4 expression was reportedly rare in conven- tional osteosarcoma, we hypothesized that these markers may ow-grade osteosarcomas, that is parosteal osteo- help separate dedifferentiated osteosarcoma from the conven- Lsarcoma and low-grade central osteosarcoma, com- tional type. To test this, we performed MDM2 and CDK4 im- prise a distinct subset accounting for 5% of all munohistochemistry on 81 primary and 26 recurrent/metastatic osteosarcomas. Parosteal osteosarcomas typically arise high-grade osteosarcomas and correlated these data with the on the surface of

Journal

American Journal of Surgical Pathology – Wolters Kluwer Health

Published: Mar 1, 2012

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