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Differentiation potencies of isolated parts of the urodele gastrula, by J. Holtfreter

Differentiation potencies of isolated parts of the urodele gastrula, by J. Holtfreter INTRODUCTION Thanks to the vital staining experiments of Vogt (1929) on Triturus, Axolotl and Bombimtor we possess a detailed knowledge of the topographic distribution of the organ anlagen of the early amphibian embryo, especially in the gastrula stage. The investigations showed us that in this early stage the organ primordia are still localized side by side on the surface of the embryo; they reach the final site of their differentiation by a complicated system of invagination, stretching, folding and spreading movements. For the developmental physiologist, these projections of the organ distribution in different stages of development, and the diagram of the formative movements became an invaluable basis for his experimental investigations, since they demonstrated the exact course of normal development and the prospective significancc [actual fate] of the embryonic regions while he tries to explore the potencies of these regions by means of transplantation and extirpation experiments. A very important method for the detection of the potencies of the germ regions is their isolation in a physiologically neutral medium [follows a brief survey of earlier, not very successful, isolation experiments, mostly on older embryos, e.g., isolation of heart primordial. Hence, a thorough investigation of the self-differentiation capabilities of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Developmental Dynamics Wiley

Differentiation potencies of isolated parts of the urodele gastrula, by J. Holtfreter

Hamburger, Viktor
Developmental Dynamics , Volume 205 (3) – Mar 1, 1996
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References (21)

Publisher
Wiley
Copyright
Copyright © 1996 Wiley‐Liss, Inc.
ISSN
1058-8388
eISSN
1097-0177
DOI
10.1002/(SICI)1097-0177(199603)205:3<223::AID-AJA4>3.0.CO;2-K
pmid
8850560
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTION Thanks to the vital staining experiments of Vogt (1929) on Triturus, Axolotl and Bombimtor we possess a detailed knowledge of the topographic distribution of the organ anlagen of the early amphibian embryo, especially in the gastrula stage. The investigations showed us that in this early stage the organ primordia are still localized side by side on the surface of the embryo; they reach the final site of their differentiation by a complicated system of invagination, stretching, folding and spreading movements. For the developmental physiologist, these projections of the organ distribution in different stages of development, and the diagram of the formative movements became an invaluable basis for his experimental investigations, since they demonstrated the exact course of normal development and the prospective significancc [actual fate] of the embryonic regions while he tries to explore the potencies of these regions by means of transplantation and extirpation experiments. A very important method for the detection of the potencies of the germ regions is their isolation in a physiologically neutral medium [follows a brief survey of earlier, not very successful, isolation experiments, mostly on older embryos, e.g., isolation of heart primordial. Hence, a thorough investigation of the self-differentiation capabilities of

Journal

Developmental Dynamics – Wiley

Published: Mar 1, 1996

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