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References (140)
-
J Broderick, S Connolly, E Feldmann (2007)
Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working GroupCirculation, 116
-
S Holmin, T Mathiesen (2000)
Intracerebral administration of interleukin-1beta and induction of inflammation, apoptosis, and vasogenic edemaJ Neurosurg, 92
-
TD Ardizzone, X Zhan, BP Ander, FR Sharp (2007)
SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhageStroke, 38
-
T Masada, Y Hua, G Xi, GY Yang, JT Hoff, RF Keep, S Nagao (2003)
Overexpression of interleukin-1 receptor antagonist reduces brain edema induced by intracerebral hemorrhage and thrombinActa Neurochir Suppl, 86
-
E Titova, CG Kevil, RP Ostrowski, H Rojas, S Liu, JH Zhang, J Tang (2008)
Deficiency of CD18 gene reduces brain edema in experimental intracerebral hemorrhage in miceActa Neurochir Suppl, 105
-
T Nakamura, G Xi, Y Hua, T Schallert, JT Hoff, RF Keep (2004)
Intracerebral hemorrhage in mice: model characterization and application for genetically modified miceJ Cereb Blood Flow Metab, 24
-
AM Romanic, JA Madri (1994)
Extracellular matrix-degrading proteinases in the nervous systemBrain pathology (Zurich, Switzerland), 4
-
E Shohami, I Ginis, JM Hallenbeck (1999)
Dual role of tumor necrosis factor alpha in brain injuryCytokine Growth Factor Rev, 10
-
MA Rynkowski, GH Kim, MC Garrett (2009)
C3a receptor antagonist attenuates brain injury after intracerebral hemorrhageJ Cereb Blood Flow Metab, 29
-
GA Rosenberg, S Mun-Bryce, M Wesley, M Kornfeld (1990)
Collagenase-induced intracerebral hemorrhage in ratsStroke, 21
-
Y Hua, RF Keep, JT Hoff, G Xi (2007)
Brain injury after intracerebral hemorrhage: the role of thrombin and ironStroke, 38
-
X Zhang, H Li, S Hu, L Zhang, C Liu, C Zhu, R Liu, C Li (2006)
Brain edema after intracerebral hemorrhage in rats: the role of inflammationNeurol India, 54
-
AR Zazulia, MN Diringer, CP Derdeyn, WJ Powers (1999)
Progression of mass effect after intracerebral hemorrhageStroke, 30
-
L López-Cortés, R Marquez-Arbizu (2000)
Cerebrospinal fluid tumor necrosis factor-[alpha], interleukin-1 [beta], interleukin-6, and interleukin-8 as diagnostic markers of cerebrospinal fluid infection in neurosurgical patientsCrit Care Med, 28
-
JK Wasserman, LC Schlichter (2007)
Minocycline protects the blood–brain barrier and reduces edema following intracerebral hemorrhage in the ratExp Neurol, 207
-
KR Lee, GP Colon, AL Betz, RF Keep, S Kim, JT Hoff (1996)
Edema from intracerebral hemorrhage: the role of thrombinJ Neurosurg, 84
-
S Yang, T Nakamura, Y Hua, RF Keep, JG Younger, Y He, JT Hoff, G Xi (2006)
The role of complement C3 in intracerebral hemorrhage-induced brain injuryJ Cereb Blood Flow Metab, 26
-
TW Langfitt, JD Weinstein, NF Kassell, LJ Gagliardi (1964)
Transmission of increased intracranial pressure. II. Within the supratentorial spaceJ Neurosurg, 21
-
Y Jiang, J Wu, RF Keep, Y Hua, JT Hoff, G Xi (2002)
Hypoxia-inducible factor-1alpha accumulation in the brain after experimental intracerebral hemorrhageJ Cereb Blood Flow Metab, 22
-
BH Jiang, F Agani, A Passaniti, GL Semenza (1997)
V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progressionCancer Res, 57
-
JM Levine, R Snider, D Finkelstein, ME Gurol, R Chanderraj, EE Smith, SM Greenberg, J Rosand (2007)
Early edema in warfarin-related intracerebral hemorrhageNeurocrit Care, 7
-
T Kitaoka, Y Hua, G Xi, JT Hoff, RF Keep (2002)
Delayed argatroban treatment reduces edema in a rat model of intracerebral hemorrhageStroke, 33
-
P Megyeri, CS Abrahám, P Temesvári, J Kovács, T Vas, CP Speer (1992)
Recombinant human tumor necrosis factor alpha constricts pial arterioles and increases blood–brain barrier permeability in newborn pigletsNeurosci Lett, 148
-
T Hayashi, N Noshita, T Sugawara, PH Chan (2003)
Temporal profile of angiogenesis and expression of related genes in the brain after ischemiaJ Cereb Blood Flow Metab, 23
-
J Wang, SE Tsirka (2005)
Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhageBrain, 128
-
SR Coughlin (2000)
Thrombin signalling and protease-activated receptorsNature, 407
-
JM Hallenbeck (2002)
The many faces of tumor necrosis factor in strokeNat Med, 8
-
RF Keep, G Xi, Y Hua, J Xiang (2011)
Clot formation, vascular repair and hematoma resolution after ICH, a coordinating role for thrombin?Acta Neurochir Suppl, 111
-
J Wang (2010)
Preclinical and clinical research on inflammation after intracerebral hemorrhageProg Neurobiol, 92
-
CS Anderson, KD Jamrozik, RJ Broadhurst, EG Stewart-Wynne (1994)
Predicting survival for 1 year among different subtypes of stroke. Results from the Perth Community Stroke StudyStroke, 25
-
G Kusaka, M Ishikawa, A Nanda, DN Granger, JH Zhang (2004)
Signaling pathways for early brain injury after subarachnoid hemorrhageJ Cereb Blood Flow Metab, 24
-
H Cushing (1902)
Some experimental and olinical observations conoerning states of increased intracranial tensionAm J Med Sci, 124
-
K Bartha, E Dömötör, F Lanza, V Adam-Vizi, R Machovich (2000)
Identification of thrombin receptors in rat brain capillary endothelial cellsJ Cereb Blood Flow Metab, 20
-
J Wang, S Doré (2007)
Inflammation after intracerebral hemorrhageJ Cereb Blood Flow Metab, 27
-
R Bullock, AD Mendelow, GM Teasdale, DI Graham (1984)
Intracranial haemorrhage induced at arterial pressure in the rat. Part 1: description of technique, ICP changes and neuropathological findingsNeurol Res, 6
-
DW Dickson, LA Mattiace, K Kure, K Hutchins, WD Lyman, CF Brosnan (1991)
Microglia in human disease, with an emphasis on acquired immune deficiency syndromeLab Invest, 64
-
A Rosell, E Cuadrado, A Ortega-Aznar, M Hernandez-Guillamon, EH Lo, J Montaner (2008)
MMP-9-positive neutrophil infiltration is associated to blood–brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic strokeStroke, 39
-
KR Wagner, FR Sharp, TD Ardizzone, A Lu, JF Clark (2003)
Heme and iron metabolism: role in cerebral hemorrhageJ Cereb Blood Flow Metab, 23
-
CL MacLellan, G Silasi, AM Auriat, F Colbourne (2010)
Rodent models of intracerebral hemorrhageStroke, 41
-
M Mayne, W Ni, HJ Yan, M Xue, JB Johnston, MR Bigio, J Peeling, C Power (2001)
Antisense oligodeoxynucleotide inhibition of tumor necrosis factor-alpha expression is neuroprotective after intracerebral hemorrhageStroke, 32
-
F Rincon, SA Mayer (2008)
Clinical review: critical care management of spontaneous intracerebral hemorrhageCrit Care, 12
-
M Xue, MR Bigio (2000)
Intracortical hemorrhage injury in rats: relationship between blood fractions and brain cell deathStroke, 31
-
J Castillo, A Dávalos, J Alvarez-Sabín, JM Pumar, R Leira, Y Silva, J Montaner, CS Kase (2002)
Molecular signatures of brain injury after intracerebral hemorrhageNeurology, 58
-
G Xi, KR Wagner, RF Keep, Y Hua, GM Courten-Myers, JP Broderick, TG Brott, JT Hoff (1998)
Role of blood clot formation on early edema development after experimental intracerebral hemorrhageStroke, 29
-
R Karni, Y Dor, E Keshet, O Meyuhas, A Levitzki (2002)
Activated pp 60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxiaJ Biol Chem, 277
-
J Wang, AD Rogove, AE Tsirka, SE Tsirka (2003)
Protective role of tuftsin fragment 1–3 in an animal model of intracerebral hemorrhageAnn Neurol, 54
-
Y Hua, G Xi, RF Keep, JT Hoff (2000)
Complement activation in the brain after experimental intracerebral hemorrhageJ Neurosurg, 92
-
J Wu, Y Hua, RF Keep, T Nakamura, JT Hoff, G Xi (2003)
Iron and iron-handling proteins in the brain after intracerebral hemorrhageStroke, 34
-
W Luo, Y Wang, G Reiser (2007)
Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotectionBrain Res Rev, 56
-
R Kimura, H Nakase, T Sakaki, T Taoka, T Tsuji (2003)
Vasogenic edema and VEGF expression in a rat two-vein occlusion modelActa Neurochir Suppl, 86
-
F Jaya, MN Win, MR Abdullah, MR Abdullah, JM Abdullah (2002)
Stroke patterns in Northeast Malaysia: a hospital-based prospective studyNeuroepidemiology, 21
-
J Alvarez-Sabín, P Delgado, S Abilleira, CA Molina, J Arenillas, M Ribó, E Santamarina, M Quintana, J Monasterio, J Montaner (2004)
Temporal profile of matrix metalloproteinases and their inhibitors after spontaneous intracerebral hemorrhage: relationship to clinical and radiological outcomeStroke, 35
-
J Aronowski, CE Hall (2005)
New horizons for primary intracerebral hemorrhage treatment: experience from preclinical studiesNeurol Res, 27
-
KR Lee, AL Betz, RF Keep, TL Chenevert, S Kim, JT Hoff (1995)
Intracerebral infusion of thrombin as a cause of brain edemaJ Neurosurg, 83
-
T Masada, Y Hua, G Xi, GY Yang, JT Hoff, RF Keep (2001)
Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonistJ Neurosurg, 95
-
H Wang, G Reiser (2003)
The role of the Ca2 + −sensitive tyrosine kinase Pyk2 and Src in thrombin signalling in rat astrocytesJ Neurochem, 84
-
RF Keep, J Xiang, SR Ennis, A Andjelkovic, Y Hua, G Xi, JT Hoff (2008)
Blood–brain barrier function in intracerebral hemorrhageActa Neurochir Suppl, 105
-
Z Suo, M Wu, BA Citron, C Gao, BW Festoff (2003)
Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activationJ Biol Chem, 278
-
C-W Lee, C-C Lin, W-N Lin, K-C Liang, S-F Luo, C-B Wu, S-W Wang, C-M Yang (2007)
TNF-alpha induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cellsAm J Physiol Lung Cell Mol Physiol, 292
-
GA Rosenberg, M Navratil (1997)
Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the ratNeurology, 48
-
GY Yang, SF Chen, H Kinouchi, PH Chan, PR Weinstein (1992)
Edema, cation content, and ATPase activity after middle cerebral artery occlusion in ratsStroke, 23
-
J Tang, J Liu, C Zhou, JS Alexander, A Nanda, DN Granger, JH Zhang (2004)
Mmp-9 deficiency enhances collagenase-induced intracerebral hemorrhage and brain injury in mutant miceJ Cereb Blood Flow Metab, 24
-
GA Rosenberg, LA Cunningham, J Wallace, S Alexander, EY Estrada, M Grossetete, A Razhagi, K Miller, A Gearing (2001)
Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell culturesBrain Res, 893
-
MJ Marinissen, J-M Servitja, S Offermanns, MI Simon, JS Gutkind (2003)
Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformationJ Biol Chem, 278
-
S Niclou, HS Suidan, M Brown-Luedi, D Monard (1994)
Expression of the thrombin receptor mRNA in rat brainCell Mol Biol (Noisy-le-Grand), 40
-
CR Gordon, RS Merchant, A Marmarou, CD Rice, JT Marsh, HF Young (1990)
Effect of murine recombinant interleukin-1 on brain oedema in the ratActa Neurochir Suppl, 51
-
AF Ducruet, BE Zacharia, ZL Hickman, BT Grobelny, ML Yeh, SA Sosunov, ES Connolly (2009)
The complement cascade as a therapeutic target in intracerebral hemorrhageExp Neurol, 219
-
J Wu, S Yang, G Xi, S Song, G Fu, RF Keep, Y Hua (2008)
Microglial activation and brain injury after intracerebral hemorrhageActa Neurochir Suppl, 105
-
C Gong, JT Hoff, RF Keep (2000)
Acute inflammatory reaction following experimental intracerebral hemorrhage in ratBrain Res, 871
-
SM Thomas, JS Brugge (1997)
Cellular functions regulated by Src family kinasesAnnu Rev Cell Dev Biol, 13
-
Y Silva, R Leira, J Tejada, JM Lainez, J Castillo, A Dávalos (2005)
Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhageStroke, 36
-
T Tang, X-J Liu, Z-Q Zhang, H-J Zhou, J-K Luo, J-F Huang, Q-D Yang, X-Q Li (2007)
Cerebral angiogenesis after collagenase-induced intracerebral hemorrhage in ratsBrain Res, 1175
-
F Sharp, DZ Liu, X Zhan, BP Ander (2008)
Intracerebral hemorrhage injury mechanisms: glutamate neurotoxicity, thrombin, and SrcActa Neurochir Suppl, 105
-
KR Lee, N Kawai, S Kim, O Sagher, JT Hoff (1997)
Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood–brain barrier permeability, and cell survival in a rat modelJ Neurosurg, 86
-
N Bruggen, H Thibodeaux, JT Palmer (1999)
VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brainJ Clin Invest, 104
-
M Xue, MR Bigio (2000)
Intracerebral injection of autologous whole blood in rats: time course of inflammation and cell deathNeurosci Lett, 283
-
SR Coughlin (1999)
How the protease thrombin talks to cellsProc Natl Acad Sci USA, 96
-
J Jośko (2003)
Cerebral angiogenesis and expression of VEGF after subarachnoid hemorrhage (SAH) in ratsBrain Res, 981
-
VW Yong, C Power, P Forsyth, DR Edwards (2001)
Metalloproteinases in biology and pathology of the nervous systemNat Rev Neurosci, 2
-
FP Nath, A Jenkins, AD Mendelow, DI Graham, GM Teasdale (1986)
Early hemodynamic changes in experimental intracerebral hemorrhageJ Neurosurg, 65
-
W Deinsberger, J Vogel, W Kuschinsky, LM Auer, DK Böker (1996)
Experimental intracerebral hemorrhage: description of a double injection model in ratsNeurol Res, 18
-
Y Gong, GH Xi, RF Keep, JT Hoff, Y Hua (2005)
Complement inhibition attenuates brain edema and neurological deficits induced by thrombinActa Neurochir Suppl, 95
-
WD Freeman, KM Barrett, JM Bestic, JF Meschia, DF Broderick, TG Brott (2008)
Computer-assisted volumetric analysis compared with ABC/2 method for assessing warfarin-related intracranial hemorrhage volumesNeurocrit Care, 9
-
A Lu, Y Tang, R Ran, TL Ardizzone, KR Wagner, FR Sharp (2006)
Brain genomics of intracerebral hemorrhageJ Cereb Blood Flow Metab, 26
-
F-P Huang, G Xi, RF Keep, Y Hua, A Nemoianu, JT Hoff (2002)
Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation productsJ Neurosurg, 96
-
C Venkatasubramanian, M Mlynash, A Finley-Caulfield, I Eyngorn, R Kalimuthu, RW Snider, CA Wijman (2011)
Natural history of perihematomal edema after intracerebral hemorrhage measured by serial magnetic resonance imagingStroke, 42
-
M Rodríguez-Yáñez, M Castellanos (2005)
Molecular signatures of course and prognosis of intracerebral hemorrhageSeminars in Cerebrovascular Diseases and Stroke, 5
-
CA Séguin, RM Pilliar, JA Madri, RA Kandel (2008)
TNF-alpha induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degenerationSpine, 33
-
G-Q Zheng, X-T Wang, X-M Wang, R-R Gao, X-L Zeng, X-L Fu, Y Wang (2009)
Long-time course of protease-activated receptor-1 expression after intracerebral hemorrhage in ratsNeurosci Lett, 459
-
JP Broderick, HP Adams, W Barsan (1999)
Guidelines for the management of spontaneous intracerebral hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart AssociationStroke, 30
-
HW Pia, C Langmaid, J Zierski (1980)
Spontaneous intracerebral haematomas -
Y Hua, J Wu, RF Keep, T Nakamura, JT Hoff, G Xi (2006)
Tumor necrosis factor-alpha increases in the brain after intracerebral hemorrhage and thrombin stimulationNeurosurgery, 58
-
G Xi, Y Hua, RF Keep, JG Younger, JT Hoff (2001)
Systemic complement depletion diminishes perihematomal brain edema in ratsStroke, 32
-
SJ Weiss (1989)
Tissue destruction by neutrophilsN Engl J Med, 320
-
T Dziedzic, S Bartus, A Klimkowicz, M Motyl, A Slowik, A Szczudlik (2002)
Intracerebral hemorrhage triggers interleukin-6 and interleukin-10 release in bloodStroke, 33
-
KR Lee, AL Betz, S Kim, RF Keep, JT Hoff (1996)
The role of the coagulation cascade in brain edema formation after intracerebral hemorrhageActa Neurochir (Wien), 138
-
M Xue, MD Hollenberg, VW Yong (2006)
Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in miceJ Neurosci, 26
-
S Suzuki, RE Kelley, BK Dandapani, Y Reyes-Iglesias, WD Dietrich, RC Duncan (1995)
Acute leukocyte and temperature response in hypertensive intracerebral hemorrhageStroke, 26
-
T-N Lin, S-W Sun, W-M Cheung, F Li, C Chang (2002)
Dynamic changes in cerebral blood flow and angiogenesis after transient focal cerebral ischemia in rats. Evaluation with serial magnetic resonance imagingStroke, 33
-
G Wu, FP Huang (2005)
Effects of venom defibrase on brain edema after intracerebral hemorrhage in ratsActa Neurochir Suppl, 95
-
C Counsell, S Boonyakarnkul (1995)
Primary intracerebral haemorrhage in the Oxfordshire community stroke projectCerebrovascular, 5
-
CS Anderson, TM Chakera, EG Stewart-Wynne, KD Jamrozik (1994)
Spectrum of primary intracerebral haemorrhage in Perth, Western Australia, 1989–90: incidence and outcomeJ Neurol Neurosurg Psychiatr, 57
-
RG Holloway, DM Witter, KB Lawton, J Lipscomb, G Samsa (1996)
Inpatient costs of specific cerebrovascular events at five academic medical centersNeurology, 46
-
G Xi, RF Keep, JT Hoff (2006)
Mechanisms of brain injury after intracerebral haemorrhageLancet Neurol, 5
-
C Power, S Henry, MR Bigio, PH Larsen, D Corbett, Y Imai, VW Yong, J Peeling (2003)
Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinasesAnn Neurol, 53
-
N Maggio, E Shavit, J Chapman, M Segal (2008)
Thrombin induces long-term potentiation of reactivity to afferent stimulation and facilitates epileptic seizures in rat hippocampal slices: toward understanding the functional consequences of cerebrovascular insultsJ Neurosci, 28
-
LE Nee, T McMorrow, E Campbell, C Slattery, MP Ryan (2004)
TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cellsKidney Int, 66
-
A Rosell, A Ortega-Aznar, J Alvarez-Sabín, I Fernández-Cadenas, M Ribó, CA Molina, EH Lo, J Montaner (2006)
Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human strokeStroke, 37
-
JP Broderick, T Brott, T Tomsick, R Miller, G Huster (1993)
Intracerebral hemorrhage more than twice as common as subarachnoid hemorrhageJ Neurosurg, 78
-
SL Hickenbottom, JC Grotta, R Strong, LA Denner, J Aronowski (1999)
Nuclear factor-kappaB and cell death after experimental intracerebral hemorrhage in ratsStroke, 30
-
J Wang, SE Tsirka (2005)
Contribution of extracellular proteolysis and microglia to intracerebral hemorrhageNeurocrit Care, 3
-
GA Rosenberg, EY Estrada, JE Dencoff, WG Stetler-Stevenson (1995)
Tumor necrosis factor-alpha-induced gelatinase B causes delayed opening of the blood–brain barrier: an expanded therapeutic windowBrain Res, 703
-
B Bresnihan (2001)
The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritisSemin Arthritis Rheum, 30
-
M Bestué-Cardiel, J Martín-Martínez, C Iturriaga-Heras, JR Ara-Callizo, A Oliveros-Juste (1999)
Leukocytes and primary intracerebral hemorrhageRev Neurol, 29
-
R Leira, A Dávalos, Y Silva, A Gil-Peralta, J Tejada, M Garcia, J Castillo (2004)
Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factorsNeurology, 63
-
EJ Sinar, AD Mendelow, DI Graham, GM Teasdale (1987)
Experimental intracerebral hemorrhage: effects of a temporary mass lesionJ Neurosurg, 66
-
KM Bijli, M Minhajuddin, F Fazal, MA O’Reilly, LC Platanias, A Rahman (2007)
c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cellsAm J Physiol Lung Cell Mol Physiol, 292
-
G Xi, RF Keep, JT Hoff (1998)
Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in ratsJ Neurosurg, 89
-
ER Gerstner, DG Duda, E Tomaso, PA Ryg, JS Loeffler, AG Sorensen, P Ivy, RK Jain, TT Batchelor (2009)
VEGF inhibitors in the treatment of cerebral edema in patients with brain cancerNat Rev Clin Oncol, 6
-
TN Taylor, PH Davis, JC Torner, J Holmes, JW Meyer, MF Jacobson (1996)
Lifetime cost of stroke in the United StatesStroke, 27
-
T Nakamura, G Xi, J-W Park, Y Hua, JT Hoff, RF Keep (2005)
Holo-transferrin and thrombin can interact to cause brain damageStroke, 36
-
AI Qureshi, AD Mendelow, DF Hanley (2009)
Intracerebral haemorrhageLancet, 373
-
H Wang, G Reiser (2003)
Thrombin signaling in the brain: the role of protease-activated receptorsBiol Chem, 384
-
T Brott, J Broderick, R Kothari, W Barsan, T Tomsick, L Sauerbeck, J Spilker, J Duldner, J Khoury (1997)
Early hemorrhage growth in patients with intracerebral hemorrhageStroke, 28
-
D-Z Liu, BP Ander, H Xu, Y Shen, P Kaur, W Deng, FR Sharp (2010)
Blood–brain barrier breakdown and repair by Src after thrombin-induced injuryAnn Neurol, 67
-
S Abilleira, J Montaner, CA Molina, J Monasterio, J Castillo, J Alvarez-Sabín (2003)
Matrix metalloproteinase-9 concentration after spontaneous intracerebral hemorrhageJ Neurosurg, 99
-
M Castellazzi, C Tamborino, G Santis, F Garofano, A Lupato, V Ramponi, A Trentini, I Casetta, T Bellini, E Fainardi (2010)
Timing of serum active MMP-9 and MMP-2 levels in acute and subacute phases after spontaneous intracerebral hemorrhageActa Neurochir Suppl, 106
-
R Hamada, H Matsuoka (2000)
Antithrombin therapy for intracerebral hemorrhageStroke, 31
-
J Wang, S Doré (2008)
Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhageNeuroscience, 155
-
S Yang, T Nakamura, Y Hua, RF Keep, JG Younger, JT Hoff, G Xi (2006)
Intracerebral hemorrhage in complement C3-deficient miceActa Neurochir Suppl, 96
-
MA Rynkowski, GH Kim, RJ Komotar (2008)
A mouse model of intracerebral hemorrhage using autologous blood infusionNat Protoc, 3
-
W Shi, Z Wang, J Pu, R Wang, Z Guo, C Liu, J Sun, L Gao, R Zhou (2011)
Changes of blood–brain barrier permeability following intracerebral hemorrhage and the therapeutic effect of minocycline in ratsActa Neurochir Suppl, 110
-
M Inaji, H Tomita, O Tone, M Tamaki, R Suzuki, K Ohno (2003)
Chronological changes of perihematomal edema of human intracerebral hematomaActa Neurochir Suppl, 86
-
MC Garrett, ML Otten, RM Starke, RJ Komotar, P Magotti, JD Lambris, MA Rynkowski, ES Connolly (2009)
Synergistic neuroprotective effects of C3a and C5a receptor blockade following intracerebral hemorrhageBrain Res, 1298
-
E Tejima, B-Q Zhao, K Tsuji, A Rosell, K Leyen, RG Gonzalez, J Montaner, X Wang, EH Lo (2007)
Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhageJ Cereb Blood Flow Metab, 27
-
Z Suo, M Wu, S Ameenuddin, HE Anderson, JE Zoloty, BA Citron, P Andrade-Gordon, BW Festoff (2002)
Participation of protease-activated receptor-1 in thrombin-induced microglial activationJ Neurochem, 80
-
YP Han, TL Tuan, H Wu, M Hughes, WL Garner (2001)
TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMPJ Cell Sci, 114
-
MC Lee, LM Heaney, RL Jacobson, AC Klassen (1975)
Cerebrospinal fluid in cerebral hemorrhage and infarctionStroke, 6
-
TK Vu, DT Hung, VI Wheaton, SR Coughlin (1991)
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activationCell, 64
-
J Wu, Y Hua, RF Keep, T Schallert, JT Hoff, G Xi (2002)
Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhageBrain Res, 953
- Publisher
- Springer Journals
- Copyright
- Copyright © 2012 by Springer Science+Business Media, LLC
- Subject
- Biomedicine; Neurosurgery; Cardiology; Vascular Surgery; Neurosciences; Neurology
- ISSN
- 1868-4483
- eISSN
- 1868-601X
- DOI
- 10.1007/s12975-012-0162-0
- pmid
- 24323861
- Publisher site
- See Article on Publisher Site
Abstract
Intracerebral hemorrhage (ICH) is a devastating type of stroke with no effective therapies. Clinical advances in ICH treatment are limited by an incomplete understanding of the molecular mechanisms responsible for secondary injury and poor outcome. Increasing evidence suggests that cerebral edema is a major contributor to secondary injury and poor outcome in ICH. ICH activates specific signaling pathways that promote edema and damage neuronal tissue. By increasing our understanding of these pathways, we may be able to target them pharmaceutically to reduce edema in ICH patients. In this review, we focus on three major signaling pathways that promote edema after ICH: (1) the coagulation cascade and thrombin, (2) the inflammatory response and matrix metalloproteinases, and (3) the complement cascade and hemoglobin toxicity. We will describe the experimental evidence that confirms these pathways promote edema in ICH, discuss potential targets for new therapies, and comment on important directions for future research.
Journal
Translational Stroke Research – Springer Journals
Published: Apr 12, 2012