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Nanos is an RNA‐binding protein that is involved in the development and maintenance of germ cells. In combination with Pumilio, Nanos binds to the 3′ untranslated region of a messenger RNA and represses its translation. Nanos has two conserved Cys‐Cys‐His‐Cys zinc‐finger motifs that are indispensable for its function. In this study, we have determined the crystal structure of the zinc‐finger domain of zebrafish Nanos, for the first time revealing that Nanos adopts a novel zinc‐finger structure. In addition, Nanos has a conserved basic surface that is directly involved in RNA binding. Our results provide the structural basis for further studies to clarify Nanos function.
EMBO Reports – Wiley
Published: Nov 1, 2010
Keywords: ; ; ; ;
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