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References (18)
-
R. Keller, H. Altermatt, K. Nooter, G. Poschmann, J. Laissue, P. Bollinger, P. Hiestand (1992)
SDZ PSC 833, A non‐immunosuppressive cyclosporine: Its potency in overcoming P‐glycoprotein‐mediated multidrug resistance of murine leukemiaInternational Journal of Cancer, 50
-
A. Schinkel, J. Smit, O. Tellingen, J. Beijnen, E. Wagenaar, L. Deemter, C. Mol, M. Valk, E. Robanus-Maandag, H. Riele, A. Berns, P. Borst (1994)
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsCell, 77
-
James Croop, Martine Raymond, Daniel Haber, Alain Devault, J. Robert, Arceci, Philippe Gros, D. Housman (1989)
The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissuesMolecular and Cellular Biology, 9
-
A. Sparreboom, J. Asperen, U. Mayer, A. Schinkel, J. Smit, D. Meijer, P. Borst, W. Nooijen, J. Beijnen, O. Tellingen (1997)
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.Proceedings of the National Academy of Sciences of the United States of America, 94 5
-
L. Teeter, F. Becker, F. Chisari, D. Li, M. Kuo (1990)
Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomasMolecular and Cellular Biology, 10
-
D. Kohler, B. Goldspiel (1994)
Paclitaxel (Taxol)Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 14
-
(1996)
Active secretion and enterocytic drug -
A. Sparreboom, O. Tellingen, W. Nooijen, J. Beijnen (1996)
Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL.Cancer research, 56 9
-
(1994)
Pharmacokinetics of paclitaxel in experimental animals. Part I. Blood level (Japanese) -
M. Huizing, V. Misser, R. Pieters, W. Huinink, C. Veenhof, J. Vermorken, H. Pinedo, J. Beijnen (1995)
Taxanes: a new class of antitumor agents.Cancer investigation, 13 4
-
A. Sparreboom, O. Tellingen, W. Nooijen, J. Beijnen (1995)
Determination of paclitaxel and metabolites in mouse plasma, tissues, urine and faeces by semi-automated reversed-phase high-performance liquid chromatography.Journal of chromatography. B, Biomedical applications, 664 2
-
D. Boesch, C. Gavériaux, B. Jachez, A. Pourtier-Manzanedo, P. Bollinger, F. Loor (1991)
In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833.Cancer research, 51 16
-
Percy Stocks (2007)
BRITISH JOURNAL OF CANCER -
James Harris, Atiqur Rahman, Br Kim, F. Guengerich, J. Collins (1994)
Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme.Cancer research, 54 15
-
M. Shet, C. Fisher, P. Holmans, R. Estabrook (1993)
Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase.Proceedings of the National Academy of Sciences of the United States of America, 90 24
-
George Fisher, B. Lum, J. Hausdorff, B. Sikic (1996)
Pharmacological considerations in the modulation of multidrug resistance.European journal of cancer, 32A 6
-
R. Dorr (1994)
Pharmacology and Toxicology of Cremophor EL DiluentAnnals of Pharmacotherapy, 28
-
W. Mcguire, W. Hoskins, W. Hoskins, M. Brady, P. Kucera, E. Partridge, K. Look, D. Clarke‐Pearson, Martin Davidson (1996)
Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancerInternational Journal of Gynecology & Obstetrics, 54
- Publisher
- Springer Journals
- Copyright
- Copyright © 1997 by Cancer Research Campaign
- Subject
- Biomedicine; Biomedicine, general; Cancer Research; Epidemiology; Molecular Medicine; Oncology; Drug Resistance
- ISSN
- 0007-0920
- eISSN
- 1532-1827
- DOI
- 10.1038/bjc.1997.530
- Publisher site
- See Article on Publisher Site
Abstract
Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the development of a clinically useful oral formulation of paclitaxel.
Journal
British Journal of Cancer – Springer Journals
Published: Nov 1, 1997