Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

The murine β‐chemokine TARC is expressed by subsets of dendritic cells and attracts primed CD4 + T cells

The murine β‐chemokine TARC is expressed by subsets of dendritic cells and attracts primed CD4 +... To investigate specific properties of dendritic cells (DC) which are not shared by other antigen‐presenting cells, we compared gene expression patterns of mouse DC and macrophages by differential mRNA display. One of the cDNA identified coded for a murine homolog of the human β‐chemokine, thymus and activation‐regulated chemokine (TARC). The gene is expressed in a subset of bone marrow‐derived DC and is up‐regulated after lipopolysaccharide (LPS) stimulation. In vivo, murine TARC (mTARC) is constitutively expressed by thymic DC, lymphnode DC and CD11c+ cells in the lung. No expression was detected in bone marrow‐derived macrophages and LPS‐activated B cells. Recombinant mTARC has no chemoattractant activity on naive peripheral CD4+ T cells. In contrast, mTARC induced migration of primed ovalbumin‐specific CD4+ T cells with a preference for Th2 cells during the early phase of the T cell response. These observations suggest that mTARC directs migration of antigen‐experienced T helper cells to DC in lymphoid as well as in non‐lymphoid organs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Immunology Wiley

The murine β‐chemokine TARC is expressed by subsets of dendritic cells and attracts primed CD4 + T cells

Download PDF
11 pages

Loading next page...
 
/lp/wiley/the-murine-chemokine-tarc-is-expressed-by-subsets-of-dendritic-cells-uCy6SBmnNq

References (43)

Publisher
Wiley
Copyright
© 1999 WILEY‐VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany
ISSN
0014-2980
eISSN
1521-4141
DOI
10.1002/(SICI)1521-4141(199909)29:09<2684::AID-IMMU2684>3.0.CO;2-Y
pmid
10508243
Publisher site
See Article on Publisher Site

Abstract

To investigate specific properties of dendritic cells (DC) which are not shared by other antigen‐presenting cells, we compared gene expression patterns of mouse DC and macrophages by differential mRNA display. One of the cDNA identified coded for a murine homolog of the human β‐chemokine, thymus and activation‐regulated chemokine (TARC). The gene is expressed in a subset of bone marrow‐derived DC and is up‐regulated after lipopolysaccharide (LPS) stimulation. In vivo, murine TARC (mTARC) is constitutively expressed by thymic DC, lymphnode DC and CD11c+ cells in the lung. No expression was detected in bone marrow‐derived macrophages and LPS‐activated B cells. Recombinant mTARC has no chemoattractant activity on naive peripheral CD4+ T cells. In contrast, mTARC induced migration of primed ovalbumin‐specific CD4+ T cells with a preference for Th2 cells during the early phase of the T cell response. These observations suggest that mTARC directs migration of antigen‐experienced T helper cells to DC in lymphoid as well as in non‐lymphoid organs.

Journal

European Journal of Immunology – Wiley

Published: Sep 1, 1999

There are no references for this article.