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Reversible Transitions between Peptide Nanotubes and Vesicle‐Like Structures Including Theoretical Modeling Studies

Reversible Transitions between Peptide Nanotubes and Vesicle‐Like Structures Including... Peptide‐based self‐assembling systems are increasingly attractive because of their wide range of applications in different fields. Peptide nanostructures are flexible with changes in the ambient conditions. Herein, a reversible shape transition between self‐assembled dipeptide nanotubes (DPNTs) and vesicle‐like structures is observed upon a change in the peptide concentration. SEM, TEM, AFM, and CD spectroscopy were used to follow this transition process. We show that dilution of a peptide‐nanotube dispersion solution results in the formation of vesicle‐like structures, which can then be reassembled into the nanotubes by concentrating the solution. A theoretical model describing this shape‐transition phenomenon is presented to propose ways to engineer assembling molecules in order to devise other systems in which the morphology can be tuned on demand. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry - A European Journal Wiley

Reversible Transitions between Peptide Nanotubes and Vesicle‐Like Structures Including Theoretical Modeling Studies

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References (40)

Publisher
Wiley
Copyright
Copyright © 2008 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0947-6539
eISSN
1521-3765
DOI
10.1002/chem.200800012
pmid
18478616
Publisher site
See Article on Publisher Site

Abstract

Peptide‐based self‐assembling systems are increasingly attractive because of their wide range of applications in different fields. Peptide nanostructures are flexible with changes in the ambient conditions. Herein, a reversible shape transition between self‐assembled dipeptide nanotubes (DPNTs) and vesicle‐like structures is observed upon a change in the peptide concentration. SEM, TEM, AFM, and CD spectroscopy were used to follow this transition process. We show that dilution of a peptide‐nanotube dispersion solution results in the formation of vesicle‐like structures, which can then be reassembled into the nanotubes by concentrating the solution. A theoretical model describing this shape‐transition phenomenon is presented to propose ways to engineer assembling molecules in order to devise other systems in which the morphology can be tuned on demand.

Journal

Chemistry - A European JournalWiley

Published: Mar 27, 2010

Keywords: ; ; ; ;

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