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Drawing a double-edged sword

Drawing a double-edged sword NEWS AND VIEWS IMMUNOLOGY---- - - - - ----- ----- ---- ---------- - the essential components of hypersensitiv­ ity reactions . Receptors for immunoglo­ bulin on mast cells on other cells of (and haematopoietic origin) are multimeric Harvey R. Colten complexes derived from several genes . So WHILE cruising the Mediterranean however, and to be examples of a much by targeting the common subunit y-gene, aboard the Prince of Monaco's yacht, broader set of immunological reactions. Sylvestre and Ravetch and Takai et al. Charles Richet and Paul Portier began a These were early indications that in­ were a ble to delete both IgE Fe (FcERl) set of experiments that led to their discov­ flammation is a dual weapon - one that is and IgG Fe (FcyRI, FcyRIII) receptors ; ery of anaphylaxis, a sudden devastating critical for host defence, but also a potent likewise, Dombrowicz et al.) selectively immunological reaction, and to the Nobel trigger of serious, even fatal. disease. deleted the lgE Fe receptor by targeting Prize in Physiology or Medicine for Richet Ninety years on from the observations its specific £Y-chain. In both strains of in 1913 (see illustration on next page) . The of Richet, Portier http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Drawing a double-edged sword

Colten, Harvey R.
Nature , Volume 371 (6497) – Oct 6, 1994
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References (10)

Publisher
Springer Journals
Copyright
Copyright © 1994 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/371474a0
Publisher site
See Article on Publisher Site

Abstract

NEWS AND VIEWS IMMUNOLOGY---- - - - - ----- ----- ---- ---------- - the essential components of hypersensitiv­ ity reactions . Receptors for immunoglo­ bulin on mast cells on other cells of (and haematopoietic origin) are multimeric Harvey R. Colten complexes derived from several genes . So WHILE cruising the Mediterranean however, and to be examples of a much by targeting the common subunit y-gene, aboard the Prince of Monaco's yacht, broader set of immunological reactions. Sylvestre and Ravetch and Takai et al. Charles Richet and Paul Portier began a These were early indications that in­ were a ble to delete both IgE Fe (FcERl) set of experiments that led to their discov­ flammation is a dual weapon - one that is and IgG Fe (FcyRI, FcyRIII) receptors ; ery of anaphylaxis, a sudden devastating critical for host defence, but also a potent likewise, Dombrowicz et al.) selectively immunological reaction, and to the Nobel trigger of serious, even fatal. disease. deleted the lgE Fe receptor by targeting Prize in Physiology or Medicine for Richet Ninety years on from the observations its specific £Y-chain. In both strains of in 1913 (see illustration on next page) . The of Richet, Portier

Journal

Nature – Springer Journals

Published: Oct 6, 1994

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