Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Essential tremor treated with propranolol: Lack of correlation between clinical effect and plasma propranolol levels

Essential tremor treated with propranolol: Lack of correlation between clinical effect and plasma... Five patients with essential tremor were treated with increasing daily doses of propranolol. Tremor intensity was assessed after each propranolol dose had been given daily for a period of at least seven days. The evaluation was made 12 to 15 hours after the last propranolol ingestion. It include a semiquantitative clinical tremor evaluation and quantitative registration with an accelerometer. Electronic integration of the accelerometer curves gave an arbitrary measure of tremor intensity. Plasma propranolol concentration was determined at each tremor measurement. The reduction in tremor correlated with increasing propranolol doses, whereas plasma propranolol concentrations varied among individuals and could not be correlated with tremor reduction. Most of the patients had considerable diminution in tremor at low propranolol doses, often with an unmeasurable plasma propranolol concentration. Determination of plasma concentrations has little value in long‐term treatment of essential tremor with propranolol. The dosage can be sufficiently guided by clinical evaluation of effect. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Essential tremor treated with propranolol: Lack of correlation between clinical effect and plasma propranolol levels

Download PDF
5 pages

Loading next page...
 
/lp/wiley/essential-tremor-treated-with-propranolol-lack-of-correlation-between-uThp0sSaaG

References (21)

Publisher
Wiley
Copyright
Copyright © 1981 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.410090110
pmid
7212666
Publisher site
See Article on Publisher Site

Abstract

Five patients with essential tremor were treated with increasing daily doses of propranolol. Tremor intensity was assessed after each propranolol dose had been given daily for a period of at least seven days. The evaluation was made 12 to 15 hours after the last propranolol ingestion. It include a semiquantitative clinical tremor evaluation and quantitative registration with an accelerometer. Electronic integration of the accelerometer curves gave an arbitrary measure of tremor intensity. Plasma propranolol concentration was determined at each tremor measurement. The reduction in tremor correlated with increasing propranolol doses, whereas plasma propranolol concentrations varied among individuals and could not be correlated with tremor reduction. Most of the patients had considerable diminution in tremor at low propranolol doses, often with an unmeasurable plasma propranolol concentration. Determination of plasma concentrations has little value in long‐term treatment of essential tremor with propranolol. The dosage can be sufficiently guided by clinical evaluation of effect.

Journal

Annals of Neurology – Wiley

Published: Jan 1, 1981

There are no references for this article.