Abstract

PostScript for the original values and for the logarithmic LETTER transformed values. Furthermore, analysis of variance (ANOVA) and linear mixed models Production of IL12p70 and IL23 with a unstructured correlation matrix for the by monocyte-derived dendritic residuals to account for dependencies (due to repeated measurements) were used. cells in children with Within the two patient groups, there was a inflammatory bowel disease high variability in IL12p70 and/or IL23 production upon microbial stimulation Inflammatory bowel disease (IBD) patients (fig 1A,B). The levels of either IL12 or IL23 represent a heterogeneous group of patients could not be related to disease activity that may need novel classification beyond (expressed by the Paediatric Crohn’s Disease just Crohns’ disease (CD) and ulcerative Activity Index (PCDAI) or Lightiger Colitis colitis (UC). Notably, based on patient Activity Index (LCAI), respectively), disease specifics such as genetics, disease location, location or medication. There was no differ- immune responses and drug responsiveness, it ence in cytokine production by moDCs when seems likely that early-onset IBDs represents we compared early with late IBD (for CD as a specific disease entity. Consequently, var- Figure 2 No relationship between the well as for UC). There was a clear dose- ious disease-associated effector