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Two cases of granular cell tumor (GCT) of the skin were examined immunohistochemically for the presence of S‐100 protein (S100), myelin basic protein (MBP), glial fibrillary acidic protein (GFA), serotonin, and B‐2‐microglobulin (B2M). One of the tumors was also observed by electron microscopy. The tumor cells in both cases showed positive staining for S100 and B2M. Although immunoreactive MBP was not found in the tumor cells, it was observed in the nerve fascicles and the nerve fibers in the stroma. Staining for GFA and serotonin was negative. The electron microscopic findings showed that a large number of the tumor cells appeared to be in the final stage, showing structureless cytoplasm with various granules and vacuoles. Since S100 appears to be a marker for Schwann cells, the expression of S100 by GCT supports its neural genesis.
The Journal of Dermatology – Wiley
Published: Apr 1, 1986
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