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- Publisher
- Wiley
- Copyright
- 1999 Munksgaard
- ISSN
- 1046-7408
- eISSN
- 1600-0897
- DOI
- 10.1111/j.1600-0897.1999.tb00449.x
- Publisher site
- See Article on Publisher Site
Abstract
THOMAS V.F. HVIID N D NIELS A MORLING Hriici TVF and Morling N . Sirrricul o ,fetuses und ciruses: Unicersul niechunisms oj f co-esistence with un imniiinologicul potent host. AJRI 1999; 41 :353-355 0 Miinksguard, Coperiliiigm Key words: HCMV, HLA-G, HSV, immune surveillance, spontaneous abortion THOMAS V.F. HVIID Copenhagen Hospital Corporation, Copenhagen University Hospital, Hvidovre Hospital, Department of Clinical Biochemistry 339, 30 Kettegaard Alle, DK-2650 Hvidovre, Denmark It is intriguing, in a broad immunological aspect, that the first steps in uncovering some of the strategies to evade immune surveillance and host responses in such different areas as the survival of the semi-allogenic fetus and of cells infected with certain viruses, seem to reveal clear parallels in the THOMAS V.F. HVIID mechanisms. The overall similarities between some of the molecular mechaNIELS MORLING nisms of the human extravillous trophoblast and certain viruses to evade Department of Forensic Genetics, Institute of Forensic natural killer (NK) cell surveillance are to be exploited further below. Medicine, University of In humans, the extravillous cytotrophoblast expresses the non-classical Copenhagen, 11 Frederik V's HLA class Ib protein HLA-G.' In all populations studied so far, the HLA-G Vej, DK-2100 Copenhagen 0. gene has shown very sparse polymorphism,
Journal
American Journal of Reproductive Immunology – Wiley
Published: May 1, 1999