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- Publisher
- Wiley
- Copyright
- Copyright © 1999 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 1549-3296
- eISSN
- 1552-4965
- DOI
- 10.1002/(SICI)1097-4636(19991205)47:3<324::AID-JBM6>3.0.CO;2-Y
- Publisher site
- See Article on Publisher Site
Abstract
Blends of biodegradable polymers, poly(caprolactone) and poly(D,L‐lactic‐co‐glycolic acid), have been examined as scaffolds for applications in bone tissue engineering. Hydroxyapatite granules have been incorporated into the blends and porous discs were prepared. Mechanical properties and degradation rates in vitro of the composites were determined. The discs were seeded with rabbit bone marrow or cultured bone marrow stromal cells and incubated under physiological conditions. Polymer/ceramic scaffolds supported cell growth throughout the scaffold for 8 weeks. Scanning and transmission electron microscopy, and histological analyses were used to characterize the seeded composites. This study suggests the feasibility of using novel polymer/ceramic composites as scaffold in bone tissue engineering applications. © 1999 John Wiley & Sons, Inc. J Biomed Mater Res, 47, 324–335, 1999.
Journal
Journal of Biomedical Materials Research Part A – Wiley
Published: May 5, 1999
Keywords: ; ; ; ;