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Hepatitis B virus. The major etiology of hepatocellular carcinoma

Hepatitis B virus. The major etiology of hepatocellular carcinoma CHARLES S. MOTT PRIZE Hepatitis B Virus The Major Etiology of Hepatocellular Carcinoma R. PALMER BEASLEY EPATOCELLULAR CARCINOMA (HCC) is one of the HEPADNA. A few adventuresome souls, noting that H most common cancers in the world, perhaps even macronodular cirrhosis was an occasional sequelae of the most common. There is, however, striking geo- hepatitis B infection, and that HCC usually occurred in graphic variation in its incidence throughout the world; livers with macronodular cirrhosis, suggested that HBV in much of Asia, especially China, and sub-Saharan might be a cause of HCC. Yet for a number of reasons, Africa it is one of the leading malignancies, while in most medical scientists considered a causal role of HBV most Western countries it is rare-ranking 25th among in the etiology of HCC to be highly improbable and cancers in the United States, for example. A general hardly worthy of pursuit. recognition of the enormously high incidence of HCC Negative attitudes: The major reasons for these nega- has only come about recently, in part because good tive attitudes were as follows: (1) after many years of diagnostic methods and good health statistics have gen- enormous but unsuccessful effort to find viral causes http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Wiley

Hepatitis B virus. The major etiology of hepatocellular carcinoma

Beasley, R. Palmer
Cancer , Volume 61 (10) – Mar 15, 1989
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Publisher
Wiley
Copyright
"Copyright © 1988 Wiley Subscription Services, Inc., A Wiley Company"
ISSN
0008-543X
eISSN
1097-0142
DOI
10.1002/1097-0142(19880515)61:10<1942::AID-CNCR2820611003>3.0.CO;2-J
Publisher site
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Abstract

CHARLES S. MOTT PRIZE Hepatitis B Virus The Major Etiology of Hepatocellular Carcinoma R. PALMER BEASLEY EPATOCELLULAR CARCINOMA (HCC) is one of the HEPADNA. A few adventuresome souls, noting that H most common cancers in the world, perhaps even macronodular cirrhosis was an occasional sequelae of the most common. There is, however, striking geo- hepatitis B infection, and that HCC usually occurred in graphic variation in its incidence throughout the world; livers with macronodular cirrhosis, suggested that HBV in much of Asia, especially China, and sub-Saharan might be a cause of HCC. Yet for a number of reasons, Africa it is one of the leading malignancies, while in most medical scientists considered a causal role of HBV most Western countries it is rare-ranking 25th among in the etiology of HCC to be highly improbable and cancers in the United States, for example. A general hardly worthy of pursuit. recognition of the enormously high incidence of HCC Negative attitudes: The major reasons for these nega- has only come about recently, in part because good tive attitudes were as follows: (1) after many years of diagnostic methods and good health statistics have gen- enormous but unsuccessful effort to find viral causes

Journal

Cancer – Wiley

Published: Mar 15, 1989

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