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References (15)
-
A. Fauci, K. Pratt, G. Whalen (1976)
Activation of human B lymphocytes. II. Cellular interactions in the PFC response of human tonsillar and peripheral blood B lymphocytes to polyclonal activation by pokeweed mitogen.Journal of immunology, 117 6
-
L. Östberg, J. Lindblom, P. Peterson (1976)
β2 ‐Microglobulin on the cell surface Specificity of inhibition of the mixed leukocyte reaction and mitogenic properties of antibodies against the two HLA antigen polypeptide chainsEuropean Journal of Immunology, 6
-
G. Corradin, J. Chiller (1979)
Lymphocyte specificity to protein antigens. II. Fine specificity of T- cell activation with cytochrome c and derived peptides as antigenic probesThe Journal of Experimental Medicine, 149
-
L. Adorini, M. Harvey, A. Miller, E. Sercarz (1979)
Fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg-white lysozyme in a genetically nonresponder mouse strainThe Journal of Experimental Medicine, 150
-
D. Sachs, J. Berzofsky, C. Fathman, D. Pisetsky, A. Schechter, R. Schwartz (1977)
The immune response to staphylococcal nuclease: a probe of cellular and humoral antigen-specific receptors.Cold Spring Harbor symposia on quantitative biology, 41 Pt 1
-
E. Reinherz, P. Kung, G. Goldstein, S. Schlossman (1979)
Further characterization of the human inducer T cell subset defined by monoclonal antibody.Journal of immunology, 123 6
-
E. Reinherz, P. Kung, G. Goldstein, S. Schlossman (1979)
Separation of functional subsets of human T cells by a monoclonal antibody.Proceedings of the National Academy of Sciences of the United States of America, 76 8
-
E. Reinherz, P. Kung, J. Pesando, J. Ritz, G. Goldstein, S. Schlossman (1979)
Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expressionThe Journal of Experimental Medicine, 150
-
P. Kung, G. Goldstein, E. Reinherz, S. Schlossman (1979)
Monoclonal antibodies defining distinctive human T cell surface antigens.Science, 206 4416
-
R. Humphreys, J. McCune, L. Chess, H. Herrman, D. Malenka, D. Mann, P. Parham, S. Schlossman, J. Strominger (1976)
Isolation and immunologic characterization of a human. B-lymphocyte- specific, cell surface antigenThe Journal of Experimental Medicine, 144
-
E. Reinherz, P. Kung, G. Goldstein, S. Schlossman (1980)
A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2.Journal of immunology, 124 3
-
R. McCalmon, R. Kubo, H. Grey (1975)
Effect of anti-beta2-microglobulin on antigen and allogeneic lymphocyte-induced proliferation of human lymphocytes.Journal of immunology, 114 6
-
E. Reinherz, P. Kung, G. Goldstein, S. Schlossman (1979)
A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells.Journal of immunology, 123 3
-
P. Sondel, L. Chess, R. Macdermott, S. Schlossman (1975)
Immunologic functions of isolated human lymphocyte subpopulations. III. Specific allogeneic lympholysis mediated by human T cells alone.Journal of immunology, 114 3
-
E. Reinherz, P. Kung, G. Goldstein, R. Levey, S. Schlossman (1980)
Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage.Proceedings of the National Academy of Sciences of the United States of America, 77 3
- Publisher
- Wiley
- Copyright
- Copyright © 1980 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
- ISSN
- 0014-2980
- eISSN
- 1521-4141
- DOI
- 10.1002/eji.1830101006
- pmid
- 6448746
- Publisher site
- See Article on Publisher Site
Abstract
The possible functional role of T cell surface antigens defined by monoclonal antibodies was investigated. Five monoclonal anti‐T cell reagents as well as an anti‐la and anti‐β2‐microglobulin antibody were examined for their effect on T cell function. It was shown that an antibody termed anti‐T3, reactive with all peripheral T cells, blocked T cell proliferative responses to soluble and cell surface antigens. This inhibition was seen when T lymphocytes were treated with as few as 104 anti‐T 3 molecules per cell. Although anti‐T 3 could block the generation of cytotoxic T cells in mixed lymphocyte culture, once generated, anti‐T3 had no effect on cytotoxicity. In addition, anti‐T 3 abrogated the ability of T cells to provide help to B cells in a pokeweed mitogen‐driven immunoglobulin system. More importantly, these functional effects were not seen with the other monoclonal antibodies. Both the appearance of this antigen in intrathymic ontogeny and its critical role in T cell function suggests that the T3 molecule is related to an important antigen recognition receptor or cell‐cell interaction molecule.
Journal
European Journal of Immunology – Wiley
Published: Oct 1, 1980